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脂多糖对人工关节无菌性松动的影响 被引量：5

Effect of LPS on the osteolysis induced by wear particles in vitro
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摘要 [目的]探讨脂多糖(LPS)促进人工关节松动的可能性。[方法]采集40例人体外周血,分离单核细胞(MOs),分组培养,A组(对照组):仅MOs;B组:MOs+超高分子聚乙烯微粒(UHMWPE,未去除LPS);C组:MOs+LPS;D组:MOs+UHMWPE(去除LPS);E组:MOs+UHMWPE(去除LPS)+LPS。培养48h后,放免法测定上清中肿瘤坏死因子α(TNF-α)、白介素6(IL-6)的含量。[结果]E组TNF-α、IL-6含量明显高于A、B、C、D组(P<0.05);B组TNF-α、IL-6较D组增高(P<0.05)。[结论]LPS对UHMWPE刺激TNF-α、IL-6分泌有协同的作用,增强了UHMWPE的溶骨效应。
作者 朱自强 段钢 汪明星 辛兵
机构地区 徐州矿务集团总医院骨科 徐州医学院附属医院骨科
出处 《中国矫形外科杂志》 CAS CSCD 北大核心 2009年第11期871-872,共2页 Orthopedic Journal of China
关键词 脂多糖 磨屑 骨溶解 溶骨因子
分类号 R687.4 [医药卫生—骨科学]
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参考文献5

  • 1Ren W,Li XH,Chen BD,et al.Erythromycin inhibit swear debris-induced osteoclastogenesis by modulation of murinemacrophage NF-kappa B activity[J].J Orthop Res,2004,1:21-29.
  • 2Xing Z,Pabst MJ,Hasty KA,et al.Accumulation of LPS by polyethylene particles decreases bone attachmentto implants[J].J Orthop Res,2006,5:959-966.
  • 3Chung YH,Chang EJ,Kim SJ.Lipopolysaccharide from prevotella nigrescens stimulates osteoclastogenesis in cocultures of bone marrow mononuclear cells and primary osteoblasts[J].J Periodontal Res,2006,4:288-296.
  • 4Bi Y,Seabold JM,Kaar SG,et al.Adherent endotoxin on orthopedic wear particles stimulates cytokine production and osteoclast differentiation[J].J Bone Miner Res,2001,11:2082-2091.
  • 5Skoglund B,Larsson L,Aspenberg PA.Bone-resorptive effects of endotoxin-contaminated high-density polyethylene particles spontaneously eliminated in vivo[J].J Bone Joint Surg,2002,5:767-773.

同被引文献90

  • 1程涛,戴闽,韦金忠,郝亮,程细高,姚浩群,帅浪.无菌性松动全髋关节假体周围界膜组织中Caspase-3表达和细胞凋亡的研究[J].中国修复重建外科杂志,2007,21(8):810-813. 被引量：16
  • 2Weiping Ren, Xiao Hua Li,Ben Chen, et al. Erythromycin in- hibit swear debris-induced osteoclastogenesis by modulation of murinemacrophage NF-kappa B activity[J]. J Orthop Res, 2004,22:21-29.
  • 3Xing Z, Pabst MJ, Hasty KA, et al. Accumulation of LPS by po- lyethylene particles decreases bone attachmentto implants[J]. J Orthop Res,2006,24 (5) : 959-996.
  • 4Chung YH, Chang EJ, Kim SJ. Lipopolysaccharide from Prevo- tella nigrescens stimulates osteoelastogenesis in cocultures of bone marrow mononuclear cells and primary osteoblasts[J]. J Periodontal Res,2006,41 (4) :288-96.
  • 5Gagnon F, Knoernschild KL, Payant L, et al. Endotoxin affinity for provisional restorative resins[J]. J Prosthodont, 1994,3 : 228 -236.
  • 6Hitchins VM,Merritt K. Decontaminating particles exposed to bacterial endotoxin(LPS) [J]. J Biomed Mater Res, 1999,46: 434-437.
  • 7Xavier Flecher, Christelle Rolland, Emmanuel Rixrath, et al. Local and Systemic Activation of the Mononuclear Phagocyte System in Aseptic Loosening of Total Hip J Clin Immunol, 2009,29:681-690.
  • 8Goodman S.Wear particulate and osteolysis[J].Orthop Clin N Am,2005,1:41-48.
  • 9Sundfeldt M,Carlsson LV,Johansson CB,et al.Aseptic loosening,not only a question of wear:a review of different theories[J].Acta Orthop,2006,2:177-197.
  • 10Sabokbar A,Kudo O,Athanasou NA.Two distinct cellular mechanisms of osteoclast formation and bone resorption in periprosthetic osteolysis[J].J Orthop Res,2003,21:73-80.

引证文献5

二级引证文献14

中国矫形外科杂志
2009年 第11期

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