人类乳头状瘤病毒与肺癌的病因关系研究(续)

Etiologic relationship between the hpv infection and development of lung cancer

为研究人类乳头状瘤病毒（HPV）与肺癌发生的病因关系，采用聚合酶链（PCR）技术对石蜡包埋肺鳞癌、肺腺癌、肺鳞癌组织旁鳞状化生上皮、正常支气管粘膜进行HPV6／11、8、16、18、31／33及35型检测。结果表明：4种组织中，HPVDNA的总检出率分别为58％、33％、80％和13％，其中以HPV16型及HPV18型所占比例最高，HPV感染与肺鳞癌和腺癌的发生有一定的联系，鳞状上皮化生似可视为癌前病变。

The studies was ondueted in order to observe etiologie relationship between the HPV infection and developmetn of lung cancer.Method:The formalin-fixed paraffin-embedded tissues of squamous cell carcinoma,adenocrcinoma of lung,squamous epithelium mtaplasia adjacent tumors and nomal bronchial mucosa were searched for the presence of human papillomavirus(HPV)serotypes 6/11,8,16,18,31/33 using ploymerase chain reaction(PVR)Technique.The results showed that the positive detected rates of HPVDNA were 5833%,80%,and 13%,Respectively in shove four tissues ,of them,thepercentages of HPV 18 and HPV16 were the most high,CONCLUSIONS:It suggested that HPV infection contribute to the development squamous cell earcinoma and adenocarcinoma of lung,The squamous epihelium metaplasia could be segarded as a precancer lesion.