磷酸肌酸钠治疗新生儿缺氧缺血性脑病合并心肌损伤的临床观察

Clinical observation on neonatal hypoxic-ischemic encephalopathy combined with myocardial damage treated by phosphocreatine

目的:探讨磷酸肌酸钠对新生儿缺氧缺血性脑病(H IE)合并心肌损害的保护作用。方法:将77例H IE合并心肌损害的患儿随机分为治疗组40例、对照组37例,治疗组加用磷酸肌酸钠,对照组采用常规治疗。观察治疗前后两组的神经系统症状、体征,NBNA评分,心功能,心肌酶的变化情况。结果:磷酸肌酸钠的疗效显著,两组间统计学差异具有显著性(P<0.05)。结论:磷酸肌酸钠能明显改善H IE合并心肌损害患儿的临床症状,促进脑及心肌细胞损伤的恢复。

Objective： To explore the protective effect of phosphocreatine on neonatal hypoxic - ischemie encephalopathy combined with myocardial damage. Methods： 77 neonates with hypoxic -ischemic encephalnpathy combined with myocardial damage were divided into treatment group （40 neonates） and control group （37 neonates） randomly, neonates in treatment group were treated by phosphocreatine, while neonates in control group adopted routine treatment. Nervous system symptoms, physical signs, NBNA scores, cardiac function and cardiac enzymes levels betore and after treatment in two groups were observed. Results： There was significant difference in the effects between two groups （P 〈 0. 05） . Conclusion： Phosphocreatine can relieve the symptoms of neonates with hypoxic - ischemie encephalopathy combined with myocardial damage and promote the recovery of the myocardial damage and brain damage.