早期反复自然流产患者血浆溶血磷脂酸水平改变的意义

Significance of changes of lysophosphatidic acid level in plasma in women with recurrent spontaneous abortion in early pregnancy

目的:探讨早期反复自然流产患者血浆溶血磷脂酸水平改变的意义。方法:采用薄层比色法测定早期反复自然流产患者30例以及同孕龄正常早孕30例和正常非孕期妇女30例外周血血浆溶血磷脂酸(Lysophosphatid ic ac id,LPA)水平。结果:早期反复自然流产患者血浆溶血磷脂酸水平(3.72±2.39)μmol/L,高于正常早孕(1.99±0.94)μmol/L及正常非孕期妇女(1.70±0.67)μmol/L,差异有统计学意义(P<0.01)。正常早孕和正常非孕期妇女血浆溶血磷脂酸水平相比差异无统计学意义(P>0.05)。结论:血浆溶血磷脂酸水平升高与早期反复自然流产有关。

Objective：To explore the significance of changes of lysophosphatidic acid （LPA） level in plasma in women with recurrent spontaneous abortion （RSA＇） in early pregnancy. Methods：The levels of LPA in plasma from 30 women with RSA,30 healthy pregnant women with the same pregnant weeks and 30 healthy non - pregnant women were detected by Thin - layer colorimetry method. Results ：The levelof LPA in plasma of RSA women [ （3.72 ±2. 39） mol/L] was significantly higher than those of healthy pregnant women [ （ 1.99 ±0. 94） mol/L and healthy non - pregnant women [ （ 1.70 ± 0. 67） tool/L] （ P 〈 0. 01 ）. There wa no signifiant differentce in LPA level in plasma between healthy pregnant women and healthy non-pregnant women （P 〉 0.05 ）. Conclusion ：The high level of LPA is related to RSA.