摘要
用ＲＴ－ＰＣＲ方法对５４例不同时期不同类型的白血病患者进行ｍｄｒ１及多药耐药相关蛋白（ＭＲＰ）的检测及１２例Ｐ－ｇｐ免疫组化检测，结果表明：在初发组三者的阳性表达分别为３３．３％、３３．３％和２５％。复发组三者的阳性表达分别为７９．１％、５４．２％和６２．５％。提示复发患者的耐药现象是与ｍｄｒ１、ＭＰＲ和Ｐ－ｇｐ有密切相关的。
Using RT PCR and immunohistochemical technique, expression levels of mdr1 and MRP were measured in 54 patients with leukemia. Overexpression of mdr1 and MRP were seen in 79.1% and 54.2% of relapsed patients respectively, while in primary cases both of the mdr1 and MRP were present in as low as 33.3%. These data indicated that overexpression of these two plays an important role in drug resistance of leukemia. In addition, leukemia cells may possess natural expression of mdr1 and MRP genes.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1998年第6期428-430,共3页
Chinese Journal of Clinical Oncology
基金
山东省自然科学基金
