1Hogan D ,Kolter R. Why are bacteria refractory to antimicrobials[ J]. Curt Opin Microbiol,2002,5 ( 5 ) :472-477.
2Higgins P G, Wisplinghoff H, Stefanik D, a al. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobacter baumannii [ J ]. J Antimicrob Chemother,2004,54(4) :821-823.
3Peleg A Y, Adams J, Paterson D L. Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii[J]. Antimicrob Agents Chemother,2007,51 ( 6 ) : 2065-2069.
4Lee A, Mao W, Warren M S, et al. Interplay between efflux pumps may provide either additive or muhiplicative effects on drug resistance [ J]. J Bacterio1,2000,182( 11 ) :3142-3150.
5Oethinger M, Kern W V, Jellen-Ritter A S, et al. Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB ettlux pump[ J]. Antimicrob Agents Chemother,2000,44 ( 1 ) :10-13.
6Piddock L J. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria [ J]. Clin Microbiol Rev, 2006, 19 (2) :382-402.
7Putman M, van Veen H W, Konings W N. Molecular properties of bacterial multidrug transporters [ J ]. Microbiol Mol Biol Rev, 2000,64 (4) :672-693.
8Magnet S, Courvalin P, Lambert T. Resistance-nodulation-cell division-type efflux pump involved in aminoglycoside resistance in Acinetobacter baumannii strain BM4454 [ J ]. Antimicrob Agents Chemother,2001,45(12) :3375-3380.
9Marchand I, Damier-Piolle L, Courvalin P, et al. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system [ J ]. Antimicrob Agents Chemother, 2004,48 ( 9 ) :3298-3304.
10Koretke K K, Lupas A N, Warren P V,et al. Evolution of two-component signal transduction [ J ]. Mol Biol Evol, 2000, 17 ( 12 ) : 1956- 1970.
4HIGGINS P G, HILMAR WISPLINGHOFF, DANUTA STEFANIK, et al. Selection of topoisomerase mutations and overexpression of adeB mRNA transcripts during an outbreak of Acinetobater baumannii [ J ]. J Antimicrob Chemother,2004,54(4) :821-823.
5LI Xian-zhi ,ZHANG Li, N IKAIDO H. Efflux pump-medicated intrinsic drug resistance in Mycobacterium smegmatis [ J ]. Antimicrob Agents Chemother ,2004,48 (7) :2415-2423.
6YIU Wai-chu, SZE LOK Chau, ELIZABETH T S Houang. Presence of active efflux systems AdeABC, AdeDE and AdeXYZ in different Acinetobacter genomic DNA groups [ J ]. J Med Microbiol, 2006, 55 : 477-478.
7ISABELLE MARCH, DAMIER-PIOLLE L, PATRIC COURVALIN, et al. Expression of the RND-type efflux pump AdeABC in Acinetobacter baumannii is regulated by the AdeRS two-component system[ J]. Antimicrob Agents Chemother,2004,48(9) :3298-3304.
10BelloH, DomingNez M, Sepulveda M, et al. Activity of imipenem and meropenem against strains of Acinetbacter baumannii isolated from va- rious Chilean hospital [ J ]. Rev Esp Quimioter, 2000, 13 (4) : 405 - 407.
