期刊文献+

广东省东莞市超重及肥胖青少年代谢综合征与糖调节异常的研究 被引量:8

Situation of impaired glucose regulation and metabolic syndrome in overweight or obesity adolescent students in Dongguan city
原文传递
导出
摘要 目的通过研究超重及肥胖对青少年空腹血糖受损(IFG)及糖耐量低减(IGT)影响的特点,了解青少年2型糖尿病(T2DM)发生和发展的过程。方法2007年5月至11月,以东莞地区3856名11—18岁在校中学生为研究对象。根据志愿的原则,对符合超重及肥胖(b/Ob)的368例男生和326例女生再抽静脉血,检测血脂、空腹血糖(FPG)和餐后2小时血糖(2hPG)、空腹胰岛素(Fins),然后根据体质指数(BMI)(暂定)标准Ⅱ分成超重组(b)和肥胖组(Ob),以11岁~和15~18岁年龄段对检测数据进行统计分析。结果(1)同年龄段两组BMI、低密度脂蛋白胆固醇(LDL-C)、胰岛素抵抗指数(IR)、IFG和IGT的比较:①女生11岁~b组的BMI值为(22.1±2.4)kg/m^2、LDL-C为(2.38±0.65)mmol/L、IR为1.15±0.58,IFG和IGT的检出率分别为3.5%和1.4%;Ob组的BMI值为(24.4±3.9)kg/m^2、LDL-C为(2.70±0.73)mmol/L、IR为1.36±0.67、IFG和IGT的检出率分别为14.6%和6.3%,两组相比的t或χ^2值分别为4.83、2.45、2.10、7.41和7.99(P值均〈0.01或〈0.05)。15—18岁b组的BMI值为(25.8±3.1)kg/m^2、LDL-C为(2.35±0.62)mmol/L、IR为1.14±0.64、IFG和IGT的检出率分别为3.1%和4.1%,Ob组的BMI值为(28.0±4.3)kg/m^2、LDL—C为(2.69±0.69)mmol/L、IR为1.43±0.84、IFG和IGT的检出率分别为12.8%和15.4%,两组相比的t或χ^2值分别为3.33、2.79、1.87、4.75和5.17(P值均〈0.01或〈0.05)。②男生11岁~b组的BMI值为(22.4±2.3)kg/m^2、LDL—C为(2.36±0.67)mmol/L、IR为1.19±0.65、IFG和IGT的检出率分别为3.6%和1.8%,Ob组的BMI值为(24.6±4.2)kg/m^2、LDL-C为(2.68±0.71)mmol/L、IR为1.44±0.89、IFG和IGT的检出率分别为13.3%和9.4%,两组相比的t或χ^2值分别为4.85、2.72、2.19、6.75和6.76(P值均〈0.01或〈0.05)。15-18岁b组的BMI值为(26.4±2.8)kg/m^2、LDL—C为(2.35±0.70)mmol/L、IR为(1.24±0.68)kg/m^2、IFG和IGT的检出率分别为4.7%和5.6%,Ob组的BMI值为(28.2±4.8)kg/m^2、LDL—C为(2.71±0.73)mmol/L、IR为1.50±0.95、IFG和IGT的检出率分别为17.9%和17.9%,两组相比的t或χ^2值分别为2.80、2.69、1.84、6.68和6.27(P值均〈0.01或〈0.05)。男生11岁-b组FPG为(4.88±0.76)mmol/L,Ob组FPG为(5.09±0.80)mmol/L,两组相比t=1.84,P〈0.05。(2)不同年龄段比较:①男生0b组11岁-的2hPG为(5.13±1.18)mmol/L,15~18岁的2hPG为(5.36±1.24)mmol/L,两组相比t=1.78,P〈0.05,接近成人的水平。男生11岁-(b/Oh)IGT阳性者有8例,阳性率为3.6%;15~18岁(b/Ob)IGT阳性者有13例,阳性率为8.9%,两年龄段相比χ^2=6.86,P〈0.01。②女生11岁~(b/Oh)IGT阳性者有5例,阳性率为2.6%;15~18岁(b/Ob)IGT阳性者有10例,阳性率为7.4%,两年龄段相比χ^2=4.02,P〈0.05。结论青少年T2DM的预防,应从预防体重超重开始,同时对有高危因素的青少年人群进行定期筛查,并对有高危因素者及早地进行干预性治疗,防止或减少糖调节异常患者(IFG、IGT)向T2DM的转化。 Objective To understand the occurrence and development of adolescent students' type 2 diabetes mellitus (T2DM) by researching the characteristics of the adolescent students' impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) effected by overweight or obesity. Methods From May to November 2007,3856 middle school students aged 11 to 18 years old in Dongguan city were enrolled in the study. Overweight or obesity ( b/Ob ) depended on three indexes : the national unified school-age children and adolescent students' body mass index (BMI) and the temporary screening classification standard Ⅱ established by the Working Group on Obesity in China, BP≥140/90 mm Hg ( 1mm Hg =0. 133 kPa) and fasting capillary whole glucose which was greater than or equal to 5.6 mmol/L. The fasting capillary whole glucose was screened by blood glucose meter from fingertips. Students who had any abnormal indexes were brought into this study. On basis of voluntary principle, blood lipid, fasting blood glucose (FPG) and 2-hour postprandial blood glucose (2 h PG), fasting insulin (Fins) of 368 male and 326 female students who conformed to these conditions were measured using their venous blood. By temporary BMI standard Ⅱ, they were divided into overweight group (b) and obesity group (Ob). Data of different age groups ( 11 to 14; 15 to 18 years old) was analyzed. Results The BMI, low density lipoprotein cholesterol (LDL-C), insulin resistance index ( IR), IFG and IGT of the same age stage in two groups were compared. The BMI value was (22. 1±2.4)kg/m^2 ,LDL-C was (2. 38 ±0. 65)mmol/L,IR was 1.15 ±0. 58 and the detection rates of IFG and IGT were 3.5% and 1.4% respectively in female students aged 11 to 14 years old in b group. In Ob group, BMI value was ( 24.4 ± 3.9 ) kg/m^2, LDL-C was ( 2.70 ± 0. 73 ) mmol/L, IR was 1.36±0. 67 and the detection rates of IFG and IGT were 14. 6% and 6. 3% respectively, t or χ^2 values of two groups which were compared were 4. 83,2.45,2. 10,7.41 and 7.99(P 〈0. 01 or P 〈0.05). BMI value was (25.8 ± 3.1 ) kg/m^2, LDL-C was (2. 35± 0. 62) mmol/L, IR was 1.14 ± 0. 64 and the detection rates of IFG and IGT were 3.1% and 4. 1% respectively in 15 to 18 years old in b group. In Ob group,BMI value was (28. 0±4. 3 ) kg/m^2, LDL-C was (2. 69 ±0. 69) mmol/L, IR was 1.43 ± 0. 84 and the detection rates of IFG and IGT were 12. 8% and 15.4% respectively, t or χ^2 values of two groups which were compared were 3.33,2. 79,1.87,4. 75 and 5. 17 ( P 〈 0.01 or P 〈 0. 05 ). BMI value was (22.4 ±2. 3 ) kg/m^2, LDL-C was (2. 36 ±0. 67)mmol/L,IR was 1.19 ±0. 65 and the detection rates of IFG and IGT were 3.6% and 1.8% respectively in male students of 11 to 14 years old in b group. In Ob group,BMI value was (24. 6 ±4. 2)kg/m^2, LDL-C was (2. 68 ± 0.71 ) mmol/L, IR was 1.44±0. 89 and the detection rates of IFG and IGT were 13.3% and 9. 4% respectively, t or χ^2 values of two groups which were compared were 4. 85,2.72,2. 19, 6.75 and 6.76(P〈0.01 or P〈0.05). BMI value was (26.4±2.8) kg/m^2,LDL-C was(2. 35 ±0.70) mmol/L,IR was 1.24 ±0. 68 and the detection rates of IFG and IGT were 4. 7% and 5.6% respectively in 15 to 18 years old in b group. In Ob group,BMI value was (28.2±4. 8) kg/m^2 ,LDL-C was (2. 71 ±0.73) mmol/L,IR was 1.50 ±0.95 and the detection rates of IFG and IGT were 17.9% and 17.9% respectively, t or χ^2 values of two groups which were compared were 2. 80,2. 69,1.84,6.68 and 6. 27 ( P 〈 0. 01 or P 〈 0. 05). The male students' FPG of 11 to 14 years old in b group was(4. 88 ±0. 76)mmol/L and FPG of Ob group was (5.09 ± 0. 80) mmol/L . Two groups were compared and t = 1.84 ( P 〈 0. 05 ). The statistical differences were all observed. We compared different age stages and found that the male students' 2-hour PG of 11 to 14 years old in Ob group was(5.13 ± 1.18) nnnol/L and the 2-hour PG of 15 to 18 years old was (5.36 ± 1.24) mmol/L. Two groups were compared and t = 1.78 (P 〈0. 05) near the adults value. Male students' IGT of 11 to 14 years old (b/Ob) had 8 positive cases and the positive detection rate was 3.6%. IGT of 15 to 18 years old (b/Ob) had 13 positive cases and the positive detection rate was 8. 9%. Two age stages were compared and χ^2 = 6. 86 ( P 〈 0. 01 ). Female students' IGT of 11 to 14 years old (b/Oh) had 5 positive cases and the positive detection rate was 2. 6%. IGT of 15 to 18 years old (b/Oh) had 10 positive cases and the positive detection rate was 7.4%. Two age stages were compared and χ^2 =4.02(P 〈0. 05). All had statistical significance. The high IGT incidence rate of b/Ob group's male and female students was in the stage of 15 - 18 years old. Male students were more obvious. Conclusion T2DM prevention among adolescent students should start with body overweight control. Meanwhile, the adolescent students with high risk factors should be screened regularly and early measures should be taken to prevent the impaired glucose regulation (IFG,IGT) transforming into T2DM.
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2009年第6期495-500,共6页 Chinese Journal of Preventive Medicine
关键词 青少年 超重 肥胖症 葡萄糖代谢障碍 糖尿病 2型 Adolescent Overweight Obesity Glucose metabolism disorders Diabetes mellitus, type 2
  • 相关文献

参考文献8

二级参考文献65

共引文献5205

同被引文献103

引证文献8

二级引证文献15

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部