唾液酸糖蛋白的合成

SYNTHESIS OF SIALOGLYCOPROTEIN

氰甲基硫基－２，３，４，６－四－Ｏ－乙酰基－β－Ｄ－吡喃半乳糖在甲醇钠的无水甲醇中生成２－亚氨基－２－甲氧基乙基－１－硫苷，后者的亚氨酸酯官能团可与伯胺反应生成脒。利用这一性质，修饰人血清白蛋白。

2Imino2methoxyethyl1thioglycoside(2) has been made from cyanomethyl thio2,3,4,6tetraOacetylβDgalactopyranoside (1).Its imidic ester function can react with primary amines to form amidine and be used to modify human serum albumin for synthesis of sialoglycoprotein.