职业性内分泌干扰物对女工生殖系统影响的研究

Effect of exposure to EDCs on female workers' reproductive system

目的:了解职业性内分泌干扰物对女工生殖系统的影响。方法:对该厂女工进行妇科体检,接触组1652例,对照组1241例。结果:接触组经量增多和早产的发生率大于对照组,差异有显著性(P<0.05);接触组宫颈囊肿、宫颈息肉、宫颈肥大患病率均大于对照组,差异有显著性(P<0.05)。结论:提示内分泌干扰物可能引起女工的月经经量增多,诱发早产;也可能是女工宫颈囊肿、宫颈息肉、宫颈肥大患病率升高的危险因素之一。

Objective： To investigate the effect of the endocrine disruptor chemicals （EDCs） on female workers＇ reproductive system function and the correlation between female reproductive disorders and EDCs. Methods： All 2893 subjects are female workers of a factory in Chongqing, with 1652 as exposed group and 1241 as control group. The data were derived from the gynecological examination. Results： The results showed that the rate of abnormal menstruation in exposed group （14.8%） was significantly（P〈0.05） higher than that in control group（11.2%）. The rate of premature birth, cervical cyst, cervical polypus, cervical hypertrophy in exposed group （ 1.9%, 23.9%, 7.2% ,4.0% ） were also significantly （P〈0.05） higher than those in control group（0.6%, 15.6%, 3.9%, 1.7% ）. Conclusion： EDCs may cause abnormal menstruation and premature birth. It may be one of the important factors for cervical cyst,cervical polypus,and cervical hypertrophy in the female workers.