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10号染色体上缺失的磷酸酶与张力蛋白同源物基因与神经发育 被引量：1

Phosphatase and Tensin Homology Deleted on Chromosome 10 and Neural Development
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摘要 10号染色体上缺失的磷酸酶与张力蛋白同源物基因(PTEN)在神经系统中具有重要作用,参与调控神经细胞的增殖、迁移、分化、凋亡和突触建立。对PTEN及其功能的深入研究将有助于更清楚的了解神经系统的发育,推动靶向PTEN的神经系统疾病治疗。 Phosphatase and tensin homology deleted on chromosome 10 （PTEN） plays an important role in the proliferation,migration, differentiation, apoptosis and synapse establishment of nervous system. Elucidation of PTEN function is helpful to understand the mechanisms of neural development,and thus may find new therapies for diseases in central nervous system using PTEN as a target.
作者 鲁利群 屈艺 母得志
机构地区 四川大学华西第二医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2009年第10期786-788,共3页 Journal of Applied Clinical Pediatrics
基金 国家自然科学基金项目资助(30825039 30770748)
关键词 10号染色体上缺失的磷酸酶与张力蛋白同源物基因 发育 神经系统 phosphatase and tensin homology deleted on chromosome 10 development nervous system
分类号 R394 [医药卫生—医学遗传学]
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参考文献20

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同被引文献23

  • 1韩宇,曹青山,常廷民,王光辉,杨承汉.食管癌中抑癌基因PTEN的表达及临床意义[J].新乡医学院学报,2007,24(2):109-110. 被引量：8
  • 2Okahara F, Itoh K, Nakagawara A, et al. Critical role of PICT - 1, a tumor suppressor candidate, in phosphatidylinositol 3,4,5 - trisphosphate signals and tumorigenic transformation[ J]. Mol Biol Cell,2006,17 (11') :4888 - 4895.
  • 3Takahashi Y, Morales FC, Kreimann EL, et al. PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling [ J]. EMBO J,2006,25 (4) :910 - 920.
  • 4Fine B, Hodakoski C, Koujak S,et al. Activation of the PI3K pathway in cancer through inhibition of PTEN by exchange factor P - REX2a [ J ]. Science ,2009,325 ( 5945 ) : 1261 - 1265.
  • 5Brisbin S,Liu J,Boudreau J,et al. A role for C. elegans Eph RTK slgnaling in PTEN regulation [ J ]. Dev Cell,2009,17 (4) :459 - 469.
  • 6Park S,Zhao D,Hatanpaa KJ,et al. RIP1 activates PI3K- Akt via a dual mechanism involving NF - kappaB - mediated inhibition of the mTOR - S6K - IRS1 negative feedback loop and down - regulation of PTEN[ J]. Cancer Res,2009,69(10) :4107 -4111.
  • 7Choi H J, Chung TW, Kim S J, et al. The AP -2alpha transcription factor is required for the ganglioside GM3 - stimulated transcriptional regulation of a PTEN gene [ J]. Glyeobiology ,2008 ,18 (5) :395 - 407.
  • 8Vinciguerra M, Sgroi A, Veyrat - Durebex C, et al. Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog ( PTEN ) via microRNA - 21 up - regulation in hepatocytes [ J ]. Hepatology,2009,49 (4) : 1176 - 1184.
  • 9Wang X, Jiang X. Post - translational regulation of PTEN [ J]. Oncogene,2008,27 (41) :5454 - 5463.
  • 10Rahdar M, J\Inoue T,Meyer T, et al. A phosphorylation - dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN [ J]. Proc Natl Acad Sci U S A,2009, 106(2) :480 -485.

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实用儿科临床杂志
2009年 第10期

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