索他洛尔对室性期前收缩患者Q-T离散度的影响

Effects of sotalol on Q-T dispersion of ventricular ex-trasystole patients

为研究索他洛尔对Q-T离散度的影响,测量良性室性期前收缩患者(n=19)应用索他洛尔(160—320mg/天)前后的Q-T。离散度(Q-T_(cd)),并与安慰剂组(n=15)作对照。结果发现索他洛尔用药后最大Q-T_c间期、最小Q-T_c间期显著延长,Q-T_(cd)显著缩小,但与安慰剂组比较差异无显著意义;安慰剂组上述3项指标各时期比较无显著变化。提示索他洛尔剂量在160—320mg/天范围内不增加Q-T_(cd)。

To study effects of sotalol on Q-T dispersion, we measured Q-Tc dispersion (Q-Tcd) in patients with benign ventricular extrasytole treated with sotalol (160-320mg/d) ( n=19 ), and compared with placebo ( n = 15 ), those treated with results showed that sotalol produced decreased Q-Tc dispersion, and increased maximun (Q-Tcmax) and minimun(Q-Tcmin) Q-Tc value ( P < 0. 05 ). But changes were not significant when compared with those of placebo group, in which three indices at different stages did not change remarkably. It was concluded that sotalol (160-320mg/d) did not increase dispersion of Q-Tcd in patients with benign ventricular extrasystole.