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β-内酰胺类抗生素作用机制及头孢菌素发展 被引量：13

The mechanism of β-lactam antibiotics and the development of cephalosporins
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摘要 综述了β-内酰胺类抗生素的结构种类.从化学结构角度阐述了β-内酰胺类抗生素的抗菌作用机制,青霉素和头孢菌素对β-内酰胺酶稳定性差异的原因及头孢菌素结构与抗菌活性之间的构效关系,并介绍了头孢菌素的代类差异和发展近况. This paper reviews the types of β-lactam antibiotics,and expounds, from the viewpoint of structure, mechanisms of β-lactam antibiotics and antibacterial activity, reasons of difference stability of and cephalosporins against β-lactamase,and the structure-activity relationships of cephalosporins. Latest chemical penicillin development has been described.
作者 于海军
机构地区 石家庄职业技术学院化学工程系
出处 《石家庄职业技术学院学报》 2009年第2期12-16,共5页 Journal of Shijiazhuang College of Applied Technology
关键词 Β-内酰胺类抗生素 青霉素 头孢菌素 构效关系 β-lactam antibiotics penicillin cephalosporins structure-activity relationship
分类号 R978.11 [医药卫生—药品]
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  • 1den Blaauwen T, Nanninga N. Topology of penicillin- binding protein 1b of Escherichia coli and topography of four antigenic determinants studied by immunocolabeling electron microscopy[J]. J Bacteriol,1990,172(1) :71
  • 2Sekiguchi K, Saito M, Yajirna R. Detection of methicillin - resistant Staphylococcus aureus (MRSA) with antibodies against synthetic peptides derived from penicillin - binding protein 2'[J]. Microbiol Immunol, 1995,39(8) :545
  • 3Hussain Z, Stoakes L, John MA, et al. Detection of methicillin resistance in primary blood culture isolates of coagulasenegative staphylococci by PCR, slide agglutination, disk diffusion, and a commercial method[J]. J Clin Microbiol,2002, 40(6) :2251
  • 4Moreira B, Boyle-Vavra S, de Jonge BL, et al. Increased production of penicillin - binding protein 2, increased detection of other penicillin - binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus au
  • 5Mitsuyama J, Takahata M, Yasuda T, et al. The mechanism of action of piperacillin- analogues in vitro; effect of the carbon number at the N- 4 position of 2,3 - dioxopiperazine on the outer membrane permeability, stability to beta - lactamase and binding
  • 6Pankuch GA, Visalli Ma. Susceptibilities of penicillin-and erythromycin - susceptible and - resistant pneumococci to HMR 3647(RU 66647), a new ketolide, compared with susceptibilities to 17 other agents [J]. Antimicrob Agents Chemother, 1998,42: 624
  • 7Mitsuyama J, Takahata M, Yasuda T, et al. The mechanism of action of piperacillin-analogues in vitro; effect of the carbon number at the N-4 position of 2,3-dioxopiperazine on the outer membrane permeability, stability to beta - lactamase and binding affi
  • 8Sun Y,Bauer MD, Lu W. Identification of the active site serine of penicillin - binding protein 2a from methicillin - resistant Staphylococcus aureus by electrospray mass spectrometry[J].J Mass Spectrom, 1998,33 (10): 1009
  • 9Schmidt LS, Botta G, Park JT. Effects of furazlocillin, a betalactam antibiotic which binds selectively to penicillin - binding protein 3, on Escherichia coli mutants deficient in other penicillin - binding proteins[J]. J Bacteriol, 1981,145 (1): 632
  • 10Korat B, Mottl H, Keck W. Penicillin - binding protein 4 of Escherichia coli :molecular cloning of the dacB gene,controlled overexpression, and alterations in murein composition [J]. Mol Microbiol, 1991; 5(3): 675

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石家庄职业技术学院学报
2009年 第2期

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