清金畅肺饮治疗慢性阻塞性肺疾病急性加重期48例

Study of Qingjinchangfei Drink for Treating 48 Cases of Acute Exacerbation Chronic Obstructive Pulmonary Disease(AECOPD)

目的观察清金畅肺饮结合西医治疗AECOPD的临床疗效。方法将84例患者随机分为采用随机数字表随机分为对照组和治疗组,治疗组采用在西医常规治疗的基础上加服中药汤剂清金畅肺饮治疗,对照组采用西医常规治疗,两组疗程均为14天,每日进行症状、体征改善记录,治疗前后进行肺功能、炎症因子如IL-8、IL-2等水平的检测。结果清金畅肺饮结合西医常规治疗COPD急性加重期,总有效率明显优于对照组,临床症状、体征、肺通气功能指标等的改善明显优于对照组,痰及血液中IL-8、ET、MDA、TNF-α水平较治疗前明显降低,IL-2水平较治疗前明显增高。结论清金畅肺饮结合西医治疗治疗COPD较之单纯西药治疗具有明显的优势。

Objective To observe the clinical efficacy of Qingjinchangfei drink for treating AECOPD. Methods We Used random number table to separate 84 patients in to two groups： treatment group and control group. The treatment group used western medicine conventional treatment and Chinese medicine decoction Qingjinchangfei drink. The control group used western medicine conventional treatment. Both two groups were 14 days treatment. We recorded the improvement of symptoms and signs everyday. We compared the lung function, inflammatory cytokines ,such as IL - 8 ,IL -2 before and after treatment in the two groups . Results The total efficient in treatment group was obviously better than that in control group. The indicators such as clinical symptoms, signs, pulmonary function indicators were obviously better than that in control group. Compared with before treatment,IL -8 ,ET,MDA and TNF -α in sputum and blood were obviously lower but IL - 2 was obviously higher. Conclusion Qingjinchangfei drink plus western medicine conventional treatment for treating AECOPD was obviously better than western medicine conventional treatment.