摘要
应用放射性PCR为基础的技术对106例系列胃癌DNA微小卫星体不稳定(MIN)进行评估,发现MIN在一个或一个以上座位者占41%(44/106例)胃癌。分析MIN与胃癌临床病理特点的关系发现,MIN在膨胀性生长方式胃癌中的表达明显高于在浸润型生长方式胃癌中的表达(P<0.005),但MIN的表达在不同的组织学类型,PTNM分期,年龄和性别没有明显区别(P>0.05)。这些发现揭示MIN可能在相当一部分胃癌,尤其是在传统上认为愈后较好的膨胀性生长方式胃癌的发生发展过程中起着非常重要的作用。
The Presence of microsatellite instability (MIN)was evaluated in a series of 106 cases ofgastric cancer (GC), using radioactive PCR - based technique. MIN at one or more Loci wasobserved in 44 (41%)of the 106 GC. The relationship of MIN with Pathologic growth patterns was assessed. The results showed that the frequency of MIN was significantly higher inexpanding type of GC compared to the infiltrative type of GC(P<0.005)No significant association with histologic type,pTNMstage,age or sex was found in our study(p>0.05). Thesefindings indicated that MIN might be an important contributor to the pathogenesis of asignificant number of GC,especially in expanding type of GC which traditionally has a betterprognosis.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
1998年第3期167-169,共3页
Cancer Research on Prevention and Treatment