苎麻叶酚酸组分抗炎作用及其机理研究

Anti-inflammatory effects and mechanism of ramie leaves

苎麻（Boehmeria nivea L．）为荨麻科苎麻属多年生宿根性植物，苎麻根、叶药用，在我国16世纪就有记载。我国民间用煎剂治疗感冒发烧，麻疹高热，尿路感染，肾炎水肿，孕妇腹痛，胎动不安，先兆流产，以及外科上用于跌打损伤，骨折，疮肿痈毒等均有一定疗效。70年代以来，我国医学上对苎麻根化学成分和药理作用曾进行过研究。本实验在实验室前期对苎麻抗炎活性部位筛选的基础上，对其酚酸组份抗炎作用及机制作了进一步的研究。

Objective：To investigate the anti-inflammatory effects and mechanism of active sections of Boehmeria nivea L. leaves.Methods： The anti-inflammatory actions of active sections from Boehmeria nivea L. leaves were studied using models of feet-acute soft-tissue injury by weight dropping with mice.The contents of IL-1β in mice＇ s paw were measure＆Effects of Boehmeria nivea leaves extracts were bserved on lipopolysaccharide（LPS）-indueed PGE2 and COX2 produced in THP-1 cells by cell culture. Results：The phenolic acids in ethyl acetate extract showed the remarkable inhibitory action on the mice tip swell, and reduced the contents of IL-β in the mouse Inflammatory tissue, and inhibited production of PGE2 and expression of COX2 in THP-1 cells. Conclusion： The phenolic acids in extracts from Boehmeria leaves showed marked：anti-inflammatory effects. Its function may be related to the inhibition of the synthesis of IL, COX2 ,PGE2.