蒙药地格达-4味汤对D-GlaN、TAA所致小鼠急性肝损伤的实验研究

The Experimental Study of Mongolian Medicine Digeda-4decoction for D-GlaN and TAA Induced Acute Liver Lesion of Mice

目的：观察地格达-4味汤对D-半乳糖胺（D—GLEN）、硫代乙酰胺（TAA）所致小鼠肝损伤的防治作用。方法：以护肝片作阳性对照，用不同肝毒剂造成小鼠急性肝损伤模型，分别测定动物血清相关指标，用t检验法比较各组间差异。结果：地格达-4味汤组可降低因D—GlaN所致肝损伤小鼠的ALT及AST（P〈0．05）；明显降低因TAA所致肝损伤小鼠的ALT及AST（P〈0．01）。结论：地格达-4味汤对以上不同肝损伤模型，有一定的防治作用，为该药的功效及应用提供了实验依据。

Aim： To observe the protection and treatment action of Digeda-4decoction for D-GlaN and TAA induced liver lesion of mice. Methods： Positively controlled with Huganpian the above-noted liver-toxic agents were administered to make acute liver lesion of mice to measure the relative indices of animal serum. Method of t-test was used to check the difference between the groups.Results：Digeda-4decoction decrease the serum ALT and AST of D-GlaN induced liver lesion mice（P 〈 0.05） ; and obviosly lower the serum ALT and AST of TAA induced liver lesion mice （ P 〈 0.01 ）. Conclusion： Digeda-4decoction has protection and treatment action on the above mentioned different liver lesion models to some extent, the test is likely to provide the experimental basis for the effect and application of this herb.