期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基因多态性对药品不良反应的影响

Review of the impact of genetic polymorphism on adverse drug reaction
下载PDF
导出
摘要 基因多态性是引起人体对药品产生的疗效和不良反应差异的重要原因,本文对近年来国内外研究中关联性确切的基因多态性与药品不良反应进行了综述,为临床合理用药提供参考. Genetic polymorphism plays an important role in the individual variation of the drug efficacy and adverse re- actions. In order to provide references for the rational administration of drug in clinical,we reviewed the exact relationship be- tween the genetic polymorphism and adverse drug reaction which had been proved by the research recent years in the world.
作者 李旸 田月洁
机构地区 山东大学药学院 山东省药品不良反应监测中心
出处 《齐鲁药事》 2009年第5期287-289,共3页 qilu pharmaceutical affairs
关键词 基因多态性 不良反应 综述 Genetic polymorphism adverse drug reaction review
分类号 R968 [医药卫生—药理学]
  • 相关文献

参考文献20

  • 1Chung WH.Hung SI,Hong HS,et al.Medical genetics:a marker for Stevens-Johnson syndrome.Nature,2004,428(6982):486.
  • 2Hung SI,Chung WH,Jee SH,et al.Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.Pharmacogenetics and Genomics,2006,16(4):297-306.
  • 3Man CB,Kwan P,Baum L,et al.Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese.Epilepsia,2007,48(5):1015-1018.
  • 4Lonjou C,Thomas L,Borot N,et al.A marker for StevensJohnson syndrome:ethnicity matters.Pharmacogenomics J,2006,6(4):265-268.
  • 5Alifirevic A,Jorgensen AL,Williamson PR,et al HLA-B locus in Caucasian patients with carbamazepine hypersensitivity.Pharmacogenomics,2006,7(6),813-818.
  • 6Lonjou C,Borot N,Sekula P,et al.A European study of HLA-Bin Steven-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs.Pharmacogenct Genomics,2008,18(2):99-107.
  • 7leiri I,Mamiya K,Urae A,et al.Stereoselective 4'-hydroxylation of phenytoin:relationship to(S)-mephenytoin polymorphism in Japanese.Br J Clin Pharmacol,1997,43:441-445.
  • 8Vander WJ.Maintenance dose requirement for phenytoin is lowered in genetically impaired drug metabolism independent of concommitant use of other antiepileptics.Ned Tijdschr Geneeskd,2001,145:312-315.
  • 9黄越,杨静芳,齐晓涟,王育琴,王维治,陈彪.CYP2C19和CYP2C9基因型与苯妥英血药浓度关系的研究[J].中华医学杂志,2004,84(20):1686-1689. 被引量：17
  • 10Aithal GP,Day CP,Kesteven P J,et al.Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications.lancet,1999,353(9154):717-719

二级参考文献17

  • 1王维治.神经病学（第4版）[M].北京:人民卫生出版社,2002.149.
  • 2Yoon YR, Shon JH, Kim MK, et al. Frequency of cytochrome P450 2C9 mutant alleles in a Korean population. Br J Clin Pharmacol, 2001, 51: 277-280.
  • 3van der Weide J, Steijns LS, van Weelden MJ, et al. The effect of genetic polymorphism of cytochrome P450 CYP2C9 on phenytoin dose requirement. Pharmacogentics, 2001, 11: 287-291.
  • 4Shimamoto JI, Ieiri A, Urae M, et al. Lack of differences in diclofenac (a substrate for CYP2C9) pharmacokinetics in healthy volunteers with respect to the single CYP2C9*3 allele. Eur J Clin Pharmacol, 2000, 56: 65-68.
  • 5Ninomiya H, Mamiya K, Matsuo S, et al. Genetic polymorphism of the CYP2C subfamily and excessive serum phenytoin concentration with central nervous system intoxication. Ther Drug Monit, 2000, 22: 230-232.
  • 6Coutts RT, Urichuk LJ. Polymorphic cytochromes P450 and drugs used in psychiatry. Cell Mol Neurobiol, 1999, 19: 325-354.
  • 7de Morais SM, Wilkinson GR, Blaisdell J, et al. The major genetic defect responsible for the polymorphism of S-mephenytoin metabolism in humans. J Biol Chem, 1994, 269: 15419-15422.
  • 8de Morais SM, Wikinson GR, Blaisdell J, et al. Identification of a new genetic defect responsible for the polymorphism of (S)-mephenytoin metabolism in Japanese. Mol Pharmacol, 1994, 46: 594-598.
  • 9Imai J, Ieiri I, Mamiya K, et al. Polymorphism of the cytochrome P450(CYP) 2C9 gene in Japanese epilepsy patients: genetic analysis of the CYP2C9 locus. Pharmacogenetics, 2000, 10: 85-89.
  • 10Kristensen VN, Kelefiotis D, Kristensen T, et al. High-throughput methods for detection of genetic variation. Biotechniques, 2001, 30: 318-322, 324, 326.

共引文献17

齐鲁药事
2009年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部