非小细胞肺癌中p27的表达及临床意义

The expression of P27 in non-small cell lung cancer

目的:研究p27蛋白在非小细胞肺癌(NSCLC)中的表达及其临床意义。方法:本研究共取111例石蜡包埋的非小细胞肺癌标本,其中30例含有癌旁组织。采用免疫组化SABC法检测p27蛋白的表达情况。结果:肺癌组织中p27的表达显著低于癌旁正常组织,差异有显著性。p27蛋白的表达均与肺癌患者的性别、年龄、肿瘤的大小、组织类型及临床分期无关,而与肺癌组织的分化程度、淋巴结转移以及患者的预后密切相关。结论:非小细胞肺癌中存在p27蛋白表达的下降。

Objective：To investigate the expression and clinical significance of p27 in no small cell lung cancer （NSCLC）. Methods： 111 paraffin--embedded NSCLC samples were composed and 30 of them included both the tumor and adjacent lung tissue. The expression of p27 was examined with SABC immunohistochemieal tech- niques. Result ：The positive expression rate of p27 in tumor lung tissue was more lower than in the adjacent non --tumor lung tissue,with a significant difference. The expression of p27 had no relationship with clinicopatho- logical factor Nsuch as sex,age, tumor size,histological type and TNM stage, but had relationship with differentiation of tumor lung tissue ,lymph node metastasis,and prognosis. Conclusion ：The expression of p27 protein is low in NSCLC.