高尿酸血症与老年患者颈动脉硬化斑块发生的临床研究

Hyperuricemia accelerate carotid plaque in older people

目的探讨高尿酸血症对老年患者颈动脉硬化斑块发生的作用。方法随机抽取2005年10月至2008年2月住院老年患者1719例，其中高尿酸血症827例，无高尿酸血症892例。记录患者一般资料，测定血糖、血尿酸、血脂，并进行螺旋CT脑血管成像或数字减影CT全脑血管造影检查。结果性别（x2=12．87，P=0．0056）、原发性高血压（x2=14．52，P=0．0023）与颈动脉硬化斑块发生显著相关。血糖升高（x2=9．16，P=0．012）、高胆固醇血症（x2=7．46，P=0．036）、低密度脂蛋白偏高（x2=6．92，P=0．038）、高尿酸血症（x2=9．02，P=0．017）与颈动脉硬化斑块发生有关。高尿酸血症患者中男性（OR=1．02，95％CI=1．12～1．66）、原发性高血压（OR=3．46，95％CI=1．19～6．01）、血糖升高（OR=2．23，95％CI=1．15～3．54）和尿酸偏高（OR=2．21，95％CI=1．13～3．46）发生颈动脉硬化斑块的危险性增加。结论高尿酸血症加快老年患者颈动脉硬化斑块的发生。

Objective To study the association between hyperuricemia and carotid plaques in older people. Methods Cluster random sampling methods were used in the investigation from Feb 2005 to oct 2008. Totally 1 719 participants grouped as hyperuri- cemia group （n= 827） and control group （n= 892） according to the results of the level of blood uric acid. All participants were screened with the CTA or DSA. Fasting blood glucose,Serum uric acid and serum lipid （cholesterol,triglyceride） were analyzed by automatic biochemical analyzer. Results Gender（x2 = 12.87, P = 0. 005 6）, hypertension（x2 = 14.52, P = 0. 002 3） ; hyperglycemia （X2 = 9.16, P= 0. 012）, high cholesterol（x2 = 7.46, P= 0. 036）, low density lipoprotein cholesterol（ X2 = 6.92, P = 0. 038）, hyperu- ricemia（x2 = 9.02, P= 0. 017） had association with carotid Plaque. Among hyperuricemia, man（OR= 1.02,95 % CI= 1.12 - 1.66）, hypertension（OR--3.46,95%CI= 1.19--6.01） ,hyperglycemia（OR=2.23,95%CI=1.15--3.54） and high level of blood uric acid （n=2.21,95%CI=1. 13-3.46） appeared to be more related to carotid Plaque. Conclusion Hyperuricemia accelerate carotid Plaque in older people.