老年患者颅内外动脉硬化与炎性因子关系的临床研究

A clinical study of extracranial-intracranial rterial sclerosis and inflammation factor

目的观察老年患者颅内外动脉硬化发生特点及其与炎性因子的关系。方法随机选择老年患者2 115例,经螺旋CT脑血管成像、数字减影CT全脑血管造影检查有无颅内外动脉硬化,进行临床资料收集和血清炎性因子测定。结果2 115例老年患者中颅内外动脉硬化311例(14.70%),无颅内外动脉硬化1 804例(85.30%)。无颅内外动脉硬化者与颅内外动脉硬化者比较血清白介素-6[(92.70±46.80)与(72.88±25.12)pg/mL]、肿瘤坏死因子[(36.27±24.11)与(33.96±14.78)g/L]及超敏C反应蛋白[(1.73±1.43)与(1.06±0.65)mg/L]检测均升高,差异有统计学意义(P<0.05)。结论颅内外动脉硬化的发生与炎性因子变化密切相关,通过炎性因子变化可以监测动脉硬化发生和转归过程。

Objectives To investigate the characteristic of extracranial-intracranial arterial sclerosis and the relationship with in- flammation factor. Methods From 2 115 participants, aged 65 years old and over, were randomly selected. All participants were screened with digital subtraction angiography （DSA）,CT angiography（CTA） and a baseline screening. At baseline screening, the following data were collected： demographic data and neuropsychological test. Results Extracranial- intracranial arterial sclerosis were more frequently happened to the extracranial of internal carotid artery（39.87 % ）, vertebral artery（15.11% ）, then to ubclavi- cal artery（ 10.29 % ）, intracranial of internal carotid artery （ 8.04 % ）, basilar artery （ 6.43 % ）, middle cerebral artery （ 6. 11 % ）, and the common carotid artery （5.14%）. Compared with without extracranial-intracranial arterial sclerosis group, the expression of IL- 6 ,TNF-a and Hs-CRP increased significantly in the blood serum in extracranial-intracranial arterial sclerosis group（P〈0.05）. Conclusion Extracranial-intracranial arterial sclerosis is relationship with inflammation factor.