2型糖尿病合并非酒精性脂肪肝相关危险因素分析

Analysis of correlated risk factors of type 2 diabetes associated with nonalcoholic fatty liver

目的:探讨影响2型糖尿病(T2DM)合并非酒精性脂肪肝(NAFL)的相关危险因素。方法:45例老年T2DM患者根据B超检查结果,分为T2DM合并NAFL组(A组,23例)与T2DM无脂肪肝组(B组,25例),对两组患者的身高、体重、收缩压(SBP)、舒张压(DBP)、空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、APO-A1、APO-B等指标进行测定分析,行肝脏超声检查,计算血浆致动脉粥样硬化指数(AIP)、体重指数(BMI)、APO-A1/APO-B。结果:A组与B组比较,SBP、DBP、BMI、TG、AIP水平明显升高(P<0.05或P<0.01),APO-A1水平明显降低,两组FPG、2hPG、HDL-C、APO-B水平、APO-A1/APO-B值差异无显著性(P>0.05)。结论:2型糖尿病合并非酒精性脂肪肝与高血压、HbA1c升高、脂代谢紊乱及肥胖等有关。

Objective： To explore the correlated risk factors associated with type 2 diabetes complicated with nonalcoholic fatty liver. Methods： 48 patients with type 2 diabetes were divided into two groups according to whether the patients presented with fatty liver or not. Height and weight, SBP, DBP, FPG, 2 hPG, HbA1c, blood lipid （TG, TC, LDL-C, HDL-C,APO- A1, APO-B）level were measured and AIP, BMI, APO-A1/APO-B was calculated in 23 cases of type 2 diabetes patients complicated with nonalcoholic fatty liver（group A）. 25 cases of type 2 diabetes patients without nonalcoholic fatty liver（group B） were taken as control.Results： SBP, DBP, HbA1c, BMI, triglycerides （TG） and AIP are higher but APO-A1 is lower in group A than that in group B （P〈0.05 or P〈0.01）.There are not significant differences between A and B groups on FPG, 2 h PG, HDL-C, APO-B, APO-A1/APO-B （P〉0.05）.Conclusion： Type 2 diabetes complicated with nonalcoholic fatty liver is related to dyslipidemia, high blood glucose and obesity.