摘要
目的:研究阿托伐他汀(ATV)对心肌缺血再灌注损伤的影响及两种ATP依赖的K+(K+-ATP)通道的作用。方法:将健康家兔随机分为对照组、ATV组、ATV+5-HD(A1组)、ATV+HMR1883(A2组)。进行30min局部缺血和30min再灌注。实验中持续监测左室舒张末期压(LVEDP)、左心室压最大变化速率(±dp/dtmax)的变化,再灌注结束后用伊文蓝和TTC染色法确定缺血和梗死心肌范围。结果:与对照组相比,ATV组及A2组的梗死面积显著减少(P<0.05),各项心功能指标在再灌注30min后明显改善(P<0.05);这种效应能够被5-HD所消除,A1组与对照组相比无显著性差异(P>0.05)。结论:ATV对心肌缺血再灌注损伤有早期保护效应,且这种作用可能与心肌线粒体KATP通道有关系。
Objective： To observe the effect of atorvastatin（ATV） on myocardial ischemia-reperfusion injury and the role of two ATP-sensitive K^＋ channels. Methods： Thirty-two rabbits were randomly divided into four groups, control group, ATV group, ATV＋5-HD（A1） group, ATV＋HMR1883（A2） group. All rabbits were subjected to 30 min ischemia and 30 min reperfusion. The max rate of rise of left ventricular pressure （＋dp/dtmax） and left ventricular end-diastolic pressure（LVEDP） were detected during the experiment. At the end of reperfusion, the area of necrosis and area of ischemia were determined by Evans blue and TTC staining. Results： Compared with the control group, the indexes of heart function were improved significantly and infarct size（AN/AAR） were reduced（P〈0.05） in ATV group and A2 group. And this effect was blocked by 5-HD. There was no statistically significant between the control group and A1 group（P〉0.05）. Conclusion： Atorvastatin exerts an early cardio protective effect against myocardial ischemia reperfusion in rabbits and mitochondrial KATP channel is likely involved in this protective mechanism.
出处
《中国医药导报》
CAS
2009年第17期43-44,共2页
China Medical Herald
