血管内皮功能障碍与肺血栓栓塞症

Endothelial Dysfunction and Pulmonary Thromboembolism

血管内皮细胞通过分泌多种血管活性因子,参与调节机体的凝血功能和血管的舒缩功能。内皮功能的障碍在肺血栓栓塞症的发生、发展中起重要作用。内皮的功能障碍一方面使促血栓形成作用增强,导致肺内血栓形成形成和进一步扩大;另一方面表现血管调节功能障碍,使肺小血管收缩导致血管阻力增加,出现急性右心功能不全,体循环衰竭而死亡。因此保护内皮细胞的生理功能,对改善肺血栓栓塞症患者的预后必将起到积极作用。

The vascular endothelium-related vasoreaetive substances regulate coagulation function and vasomotor tones. Vascular endothelial dysfunction plays an important role in the genesis and devel- opment of Pulmonary Thromboembolism,. On the one hand, Endothelial dysfunction can result in pulmonary thrombogenesis and its expanding by promoting thrombogenesis, on the other hand, it shows vascular regulatory dysfunction and can lead to acute right heart insufficiency by resulting from increased vascular resistance because of constriction of small vasculars in the lung, and then, general circulation failure and death. So, protecting the physiological function of endotheliocyte can exert positive effect in improving the prognosis of PTE.