摘要
转化生长因子β（TGF-β）家族广泛存在于生物体内,它对于组织器官纤维化起着重要作用。smad蛋白是TGF-β受体的胞内激酶底物,介导了TGF-β的胞内信号转导。TGF-β/smads信号通路与糖尿病肾病关系密切,并且存在多种负反馈调节机制,例如包膜受体水平,胞内smad蛋白及核内转录因子水平的反馈调节。深入了解TGF-β/smad信号通路的负性调节机制对于糖尿病肾病的防治至关重要。本文就TGF-β/smad信号通路的负性调节与糖尿病肾病予以综述。
Transforming growth factor β （TGF-β） family, widely existing in the biological body, which plays an important role in organ fibrosis. Smad proteins are the intracellular kinase substrate of TGF-β receptor,which mediate the TGF-β intracellular signal transduction. TGF-β/Smads signal pathway is closely related to diabetic nephropathy, and it has a variety of negative feedback regulation mechanism, such as peplos receptor level, intracellular Smad proteins and nuclear transcription factor level. It is crucial to understand the negative regulatory mechanism of TGF-β/Smad signaling pathway for the prevention and treatment of diabetic nephropathy. This article reviews negative regulation of signaling pathway of TGF-βSmad and diabetic nephropathy.
出处
《医学综述》
2009年第11期1683-1686,共4页
Medical Recapitulate
基金
国家自然科学基金(C03030206)
关键词
转化生长因子Β
SMAD
糖尿病肾病
负性调节
Transforming growth factor-β
Smad
Diabetic nephropathy
Negative feedback regulation
