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膜联蛋白Ⅰ的结构和生物学功能 被引量：2

Structure and Biological Effects of AnnexinⅠ
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摘要 膜联蛋白I（ANNX—I）是一种钙依赖的磷脂结合蛋白，是Annexins超家族中第一个被发现的成员。ANNX-I作为表皮生长因子受体激酶和蛋白酶C的磷酸化底物一磷酯酶A2的抑制物，具有多种生物学功能，包括囊泡运输、胞吐作用的膜融合、信号转导和钙离子通道的形成、调控炎性反应、细胞分化和细胞骨架蛋白间的相互作用等。本文就ANNX-I的结构组成，在细胞生长、分化、凋亡、信号转导。 ANNX- I is a calcium dependent phospholipids binding protein, and the first member of annexins superfamily. As the epidermal growth factor receptor kinase, protease C phosphorylation substrate and PLA2 inhibitor, ANNX-I has many biological effects including vesicular transport, membrane fusion in exocy- tosis, signal transduction, calcium channel formation, modulation of inflammation, cell differentiation and interaction of eytoskeleton proteins, etc. This article reviews ANNX- I about its structure, biological effects on cell growth ,differentiation, apoptosis, signal transduction and inflammation, etc. , as well as its relationship and effect with many tumor diseases.
作者 郭敦明 谈文峰 王芳
机构地区 南京医科大学第一附属医院骨科 南京医科大学第一附属医院风湿免疫科 南京医科大学第一附属医院临床实验研究室
出处 《医学综述》 2009年第12期1771-1773,共3页 Medical Recapitulate
关键词 膜联蛋白Ⅰ 生物学功能 细胞凋亡 细胞信号 肿瘤 ANNX- I Biological effect Cell apoptosis Cell signal Tumor
分类号 R392 [医药卫生—免疫学]
  • 相关文献

参考文献20

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二级参考文献18

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共引文献15

同被引文献38

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医学综述
2009年 第12期

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