LN、CD44V6在大肠癌组织中的表达及临床意义

LN AND CD44V6 EXPRESSION AND THEIR CLINICAL SIGNIFICANCE IN COLORECTAL CARCINOMA

目的:探讨层粘连蛋白(LN)和CD44V6在大肠癌组织中的表达及临床意义。方法:应用SP免疫组织化学法检测68例大肠癌组织、26例大肠腺瘤组织及18例正常大肠组织中LN和CD44V6的表达,并分析LN和CD44V6表达与大肠癌临床病理特征的关系。结果:在正常大肠粘膜逐步发展为大肠癌的过程中,基底膜缺损率和CD44V6的阳性表达逐渐增加(P<0.05,P<0.01)。大肠癌LN和CD44V6的表达与年龄、性别、发生部位和组织类型无关,与癌分化程度和Dukes分期有关(P<0.05)。结论:LN和CD44V6在大肠癌的发生发展过程中具有重要作用,可作为大肠癌浸润转移的指标。

Objective：To investigate the expression and clinical significance of LN and CD44V6 in colorectal cancer.Methods：Immunohistochemical staining was used to detect the expression of LN and CD44V6 in 68 cases colorectal cancer,26 cases colorectal adenomas and 18 cases colorectal normal tissues. And the relationship between LN,CD44V6 and clinicopathological features of colorectal cancer was also analyzed.Results： From normal colorectal tissue to colorectal cancer the LN and CD44V6 expression gradually increased （P 〈 0. 05,P 〈 0.01）.The LN and CD44V6 expression in colorectal cancer had no relations with sex,age,location and types; But were related with Dukes stage and differentiated extent. Conelusions：LN and CD44V6 may play an important role in development of colorectal carcinoma; They can be as index of invasion and metastasis of colorectal carcinoma.