摘要
目的:观察衰老大鼠不同脑区抑制性氨基酸γ-氨基丁酸(GABA)含量的变化及中药天年饮的延缓衰老作用。方法:30只SD大鼠随机分为3组,正常组、衰老模型组和天年饮用药组,每组10只大鼠。D-半乳糖连续腹腔注射制作亚急性衰老的大鼠模型。采用高效毛细管电泳法检测各组大鼠大脑皮质、海马、下丘脑抑制性氨基酸GABA的含量。结果:衰老大鼠皮质、海马、下丘脑抑制性氨基酸GABA的含量明显下降(正常组大鼠与模型组大鼠比较:P<0.01);中药天年饮可明显提高衰老大鼠各脑区GABA的含量(天年饮用药组大鼠与模型组大鼠比较:P<0.01)。结论:中药天年饮可改善衰老大鼠脑GABA的代谢,具有延缓脑老化的作用。
Objective：To observe the changes of inhibitory amino acid-γ-amino-butyric acid （GABA） content in brain of aged rats and the antiaging effects of traditional Chinese medicine tiannianyin.Methods：30 SD rats were divided into 3 groups at random： normal group, aging model group and tiannianyin group, and each group had 10 rats.The sub-acutely aging model rats were made by injecting D-gal into abdominal cavity continually. High performance capillary electropheresis （HPCE） was used to detect the contents of GABA in cerebral cortex, hippocampus and hypothalamus of rats in each group.Results：The GABA contents in cerebral cortex,hippocampus and hypothalamus of rats in aging model group decreased significantly （compared with normal rats：P 〈0.01）.Traditional Chinese medicine tiannianyin gould increase the GABA content in different brain region of aged rats obviously （tiannianyin group compared with aging model group：P 〈 0.0l）.Conclusions：Traditional Chinese medicine tiannianyin could improve the metabolism of GABA in brain of aged rats, and has effects of delaying brain ageing.
出处
《承德医学院学报》
2009年第2期129-131,共3页
Journal of Chengde Medical University
