铜绿假单胞菌对抗生素的耐药性分析

Antibiotics Resistance Analysis on P. aeruginosa

目的：分析铜绿假单胞菌的耐药性与耐药趋势。方法：按标准要求分离用半自动微生物鉴定／药敏分析系统进行菌株鉴定及药物敏感性测试。结果：2007年1月-2008年12月我院共分离出63株铜绿假单胞菌。其中对20种抗菌药物活性较好的是美洛培南、亚胺培南、头胞吡肟，耐药率为：7．0％、15．0％、17．0％，耐药率较高的是阿莫西林88．0％、头胞西丁86．0％、复方新诺明83．0％，其对阿莫西林的耐药率从77．O％升至88．O％，同期对复方新诺明的耐药率从59．2％升至83．0％。β-内酰胺类抗生素、哌拉西林耐药率有下降趋势，从57．3％降至47．0％。结论：监测显示铜绿假单胞菌对碳青霉烯类、氨基糖苷类、β-内酰胺酶抑制剂复合药物保持较好的敏感性。但三代头孢菌素的耐药率高于国家细菌耐药监测研究组（BRSSG），加强对铜绿假单胞菌耐药率有计划的连续监测对临床有指导意义。

Objective： To investigate the dynamics of resistance to antibiotics of the P. aeruginosa separated from patients in our hospital from Jan 2007 to June 2008. Methods： The characterization and sensitivity to antibiotics of P. aeruginosa were analyzed using france auto system. Results： 63 strains of P. aeruginosa were separated and characterized during the six months. The resistance rates to antibiotics of MERO, IMI, FEP, AMO, CXT and TSU were 7.0%, 15.0%, 17.0%, 88.0%, 86.0%, 83.0%. From Jan. 2007 to Jun, 2008, the resistance rate to TSU rose from 59.2% to 83. 0%. The resistance rate to β-lactam antibiotics decreased from 57.3% to 47.0%, which showed dropping tendency. Conclusion： P. aeruginosa showed positive sensitivity to Carbapenems, Aminoglycosides, β-laetam antibiotics, but resistance rates to third-gen- eration Cephalosporins were higher in our hospital than whole nation from Jan. 2007 to Jura 2008. The results suggested that the resistance of P. aeruginosa to antibiotics should be continuously monitored.