药物联合运动对肥胖糖耐量异常的干预

On Intervention of Combination of Metformin and Sports Treatment Method in Patients with Abnormal Sugar Tolerance

目的：评价二甲双胍联合运动疗法对肥胖糖耐量异常人群的干预作用。方法：将肥胖伴糖耐量异常者136人，给予步行联合口服二甲双胍，观察空腹血糖、口服葡萄糖耐量试验（OGTT）、糖脂代谢和胰岛素敏感性差异。结果：糖耐量减低明显好转，前后明显差异，体重指数、腰围、甘油三酯、游离脂肪酸下降，胰岛素敏感性明显改善。结论：运动疗法和二甲双胍二者均有减重效应，增加胰岛素敏感性，达到协同作用。建议扩大在居民区中预防肥胖糖耐量异常的人群，以防发展成2型糖尿病。

Objective： To evaluate the intervention function of combination of metformin and sports treatment method in groups of people whose sugar tolerance are abnormal. Methods： Treating 136 patients with walking method and metformin and observing blood sugar, insulin sensitivity of them. Results： The reduction of sugar tolerance and insulin sensitivity are greatly improved. Conclusion： The combination of metformin and sports treatment method is effective.