我院2005年至2007年头孢菌素类药物应用分析

Analysis of cephalosporius use between year 2005 and year 2007

目的了解我院头孢菌素类药物的临床应用情况，为临床用药提供科学的理论依据。方法分析统计2005年至2007年我院头孢菌素类药物的品种、数量、用药金额、用药频度（DDDs）、药品限定日费用（DDDc）等指标。结果3年中，头孢菌素类药物的用药金额年平均增长率为一2．09％；第三代头孢菌素用量金额最大，但DDDc增幅很小；第二代头孢菌素DDDs增长最快，但DDDc降幅最大；第四代头孢菌素DDDs增长列第二位；各代头孢菌素药物的DDDc均在下降。结论我院头孢菌素类抗生素用药逐步趋于合理，选择抗菌药应根据抗菌药物特点、临床疗效、细菌耐药、不良反应以及当地社会经济状况、药品价格等因素，结合患者体征、药敏情况等因素，制定最佳给药方案，防止浪费并减少抗菌药的不良反应和耐药菌的产生。

Objective To observe cephalosporins use between 2005 and 2007. Methods The cephalosporins used from 2005 to 2007 were statistically analyzed. Results During the 3 years, the cephalosporins use increased with an annual rate of - 2.09%. The third generation cephalosporins use is the largest with the lowest increasing rate. The second generation cephalosporins＇s DDDs showed the highest increase rate with the highest DDDc＇s decrease rate. The fourth generation cephalosporins had the 2nd DDDs increase rate. The DDDc of each generation decreased. Conclusion The cephalosporins use reasonable in Zhongshan Hospital.