摘要
目的:观察黄芪三仙汤治疗绝经后骨质疏松症的临床疗效。方法:将61例患者随机分为2组。治疗组36例服用黄芪三仙汤治疗;对照组25例服用钙尔奇D治疗。疗程均为6个月。观察临床疗效及治疗前后肾阳虚症状积分、桡尺骨骨矿含量、骨密度、骨代谢生化指标等的变化。结果:显效率和总有效率治疗组分别为66.7%和91.7%,对照组分别为36.0%和60.0%,治疗组疗效优于对照组(P<0.05)。同时可提高桡尺骨BMD、BMC及E2,降低IL-6、尿Hop/Cr及Ca/Cr(P<0.01)。结论:黄芪三仙汤可明显改善患者肾阳虚症状,其作用机制可能与提高雌激素水平,改善骨代谢,增加绝经后妇女的骨密度,抑制骨吸收作用,防止骨丢失有关。
Objective: To study the clinical curative effect of HuangQiSanXian Tang(HQSXT),a traditional Chinese medicine, on postmenopausal osteoporosis(PMOP). Methods: Sixty-one cases of PMOP were randomized into the HQSXT group(n=36) and the Callrate D 600 group(n=25),treating for 6 months. And such symptoms as newly found Yang-deficiency symptom score, bone mineral content(BMC), bone mineral density(BMD), sex hormone level, blood and urinary indexes for bone metabolism that occurred in patients were observed. Results: In the HQSXT group, the significant efficency and the total effective rate were 66.7% and 91.7%, which was significantly better than that in the Callrate D 600 group(P〈0.05).+Moreover, as compared with the Callrate D 600 group, levels in the HQSXT group of bone mineral content(BMC) bone mineral density(BMD), sex hormone level were significantly higher, interleukin 6 (IL-6), urinary hydroxyproline/creatinine, urinary calcium/creatinine were significantly lower(P〈0.01). Conclusion: the HQSXT can treat PMOP obviously improve Yang-deficiency symptom, as it could obviously increase the sex hormone level, improve a bone metabolism, increase postmenopausal women's BMD, repress a bone absorption function, and keep bone from throwing losing.
出处
《中医药导报》
2009年第5期9-11,共3页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
广东省科技计划项目(2006B35601005)
关键词
绝经后骨质疏松
黄芪三仙汤
雌激素
Postmenopausal osteoporosis
HuangQiSanXian Tang
Female sex hormon