联合检测血清PCⅢ、HA、LN对肝纤维化的诊断价值

The preliminary study on diagnostic value of co detection of serum PCⅢ HA and LN in liver fibrosis patients

目的寻找肝纤维化敏感可靠的血清学指标。方法对１４８例各种类型肝病联合检测血清Ⅲ型前胶元（ＰＣⅢ）、透明质酸（ＨＡ）、层粘连蛋白（ＬＮ），并与３４例肝组织学进行对照研究。结果三项指标分别在急性肝炎、慢性肝炎中型、重型和肝硬化中依次升高，差异有显著性（Ｐ＜０．０１或Ｐ＜０．０５）。三项指标升高与肝纤维组织增生呈同步性，显示出良好的正相关（Ｐ＜０．０１）。结论三项指标的联合检测可极大增加临床诊断的准确性和可靠性。动态观察上述指标的变化既可掌握患者病情的演变。

Objective The study was designed to establish sensitive and reliable serum marker on liver fibrosis for early clinical diagnosis. Methods We carried out co detection of serum PCⅢ, HA and LN in 148 cases with different hepatic diseases compared with liver biopsy samples of 34 cases. Results The three markers increase in the AH,CH (moderate type, severe type), cirrhosis progressively while the difference between groups were significant ( P< 0.01 or P <0.05). Rise of three markers was consistent with the degree of hepatic fibrosis and there existed positive correlation between each other ( P <0.01). Conclusion The co detection of three markers can improve the accurency and reliability of clinical diagnosis. The dynamic changement of three markers may be used to predict the trends of diseases and select effective medicine treating hepatic fibrosis.