400例老年女性乳腺癌的临床分析

Breast cancer in elderly women:clinical analysis of 400 cases

目的探讨400例60岁以上女性乳腺癌患者的临床特点、生存期及预后影响因素。方法回顾性分析解放军第307医院1985-2007年收治的400例女性乳腺癌的临床资料,并进行随访和统计分析。Kaplan-Meier法计算生存曲线,Cox回归法分析影响预后的因素。结果全组患者平均年龄65.13岁,中位无病生存期94个月,中位生存时间147个月,3、5、10年生存率分别为85%、75%、59%。Cox多因素分析显示影响预后的主要因素有临床分期、腋淋巴结转移、辅助内分泌治疗、辅助放疗激素受体。结论60岁以上乳腺癌患者的预后影响因素是临床分期、腋淋巴结转移、辅助内分泌治疗、辅助放疗和激素受体。

Objective To analyse the clinical feature, the therapeutic results and the prognostic factors of breast cancer in 400 elderly women patients aged more than 60 years. Methods The epidemio-clinical records of all the elderly women patients with breast cancer in our hospital between 1985--2007 were reviewed. Overall survival was calculated according to the Kaplan-Meier method. The multivariate analysis was performed according to the Cox model. Results The mean age was of 65.13 years. The disease free survival （DFS） was 94 months; the overall sur viral （OS） was 147 months. The 3, 5, 10 years overall survival of elder patients was of 85%, 75% and 59%, respectively. The impact factors on prognosis in univariate analysis and multivariate analysis were： clinical phase, lymph node positive, adjuvant radiation treatment and adjuvant endocrine therapy. Conclusion Clinical presentation and outcome of breast cancer in elderly patients aged more than 60 years seem to be influenced by clinical phase, lymph node positive, adjuvant radiation treatment and adjuvant endocrine therapy.