牛皮癣Ⅱ号汤剂对银屑病患者血清新蝶呤水平的影响及其临床疗效观察

Effects of Psoriasis Ⅱ Docoction on Serum Neopterin in Psoriasis Patients

目的观察牛皮癣Ⅱ号汤剂治疗血热型寻常性银屑病的疗效,探讨新蝶呤(Npt)作为评价中医药治疗银屑病的客观指标的可行性。方法选择78例血热型寻常性银屑病患者,随机分为牛皮癣Ⅱ号治疗组(38例)和消银颗粒对照组(40例),疗程2个月。ELISA法检测血清Npt水平,比较分析两组患者治疗前后PASI评分及血清Npt水平。结果治疗结束后牛皮癣Ⅱ号汤剂组(86.84%)总有效率高于消银颗粒组(67.50%)(P<0.05)。两组银屑病患者治疗前后血清Npt水平与PASI评分相平行。治疗结束后牛皮癣Ⅱ号汤剂组(7.09±2.21nmol/L)血清Npt水平低于消银颗粒组(11.45±2.17nmol/L)(P<0.05)。结论牛皮癣Ⅱ号汤剂治疗血热型寻常性银屑病疗效确切,可显著降低血清Npt水平;血清Npt水平可以作为评价中医药治疗血热型寻常性银屑病疗效的客观指标。

Objective To investigate the clinical effects of psoriasisⅡ docoction on treating blood-heat type psoriasis vulgaris, and to study the role of serum neopterin （Npt） level in measuring the effects of Chinese medicine treatment in psoriasis. Methods 78 patients of blood-heat type psoriasis vulgaris were randomly divided into two groups. 38 cases in treatment group were treated with psorioasis Ⅱ dcoction, and 40 cases in control group were treated with Xiaoyin Keli. Serum Npt level was detected by ELISA, and the relationship between serum Npt level and PASI score of the two groups was analyzed. Results The total effective rate in psorioasis lI group was higher than Xiaoyin Keli group（86.84% vs. 67.50%, X2= 4.11, P〈0.05）. There was a significant correlation between pretreatment or posnreatment Npt levels and PASI scores in all patients. After treatment, Npt levels of treated group was lower than those of control group （7.09±2.21 nmol/L vs. 11.45±2.17 nmol/L, P〈0.05）. Conclusion Psorioasis Ⅱ docoction shows a satisfactory effect on blood-heat type psoriasis vulgaris, and it can obviously lower the Npt levels. Serum Npt levels can be considered as an useful marker for measuring the effect of Chinese medicine treatment in blood-heat type psoriasis vulgaris.