脾脏原发性非霍奇金淋巴瘤10例报告

A report of 10 cases of primary spleen non-Hodgkin' s lymphomas

目的:进一步提高对脾脏原发非霍奇金淋巴瘤(NHL)的认识。方法:收集10例手术切除脾脏NHL病例进行临床病理学观察。结果:男8例,女2例。年龄16-72岁,平均44.7岁。患者以乏力消瘦,上腹部疼痛不适、发热、脾肿大为主要症状。临床Ι期8例,Π期2例。影象学检查提示脾内占位性病变,表现为多结节4例,单结节4例,粟粒样结节1例,无明显肿块1例。来源于B细胞9例,其中SMZL3例,SLL2例,DLBCL4例,T细胞PTL1例,均经免疫组化证实。结论:超声、CT、MRI影象学检查对脾脏NHL早期发现有很大帮助,明确诊断依赖组织病理学检查和免疫组化分类。

Objective ：To Study the climical feature of primary spleen non -Hodgkinh lymphomas （NHL）. Methods：Ten cases of primary spleen NHL were analysed. Results：The clinicopathological analysis of 10 patients with primary spleen NHL showed that 8 were male and 2 female, age from 16 to 72 years old（mean 44.7） ,8 cases stage Ⅰand 2 cases stage Ⅱ. All patients had hypodynamia, marasmus, abdominal pain,fever and enlarged spleen. Imageology indicated space - occupying lesion of spleen（4 cases of poly - nodule ,4 cases of single - nodule, 1 case of numerous -nodule, 1 case without obvious nodule）. Immunohistochemistry confirmed 3 cases SMZL,3 cases SLL,3 cases DL- BCL, 1 case U- PTL. Conclusion：It is very helpful to diagnose spleen NHL by B ultrasonic, CT, MRI, but its final diagnosis depends on surgical -pathology and immunohistochemistry.