纤维上皮瘤中免疫组化表型的特征及鉴别诊断意义

Characteristic and significance in differential dignosis of coimmunohistochemical expression in fibroepithelioma of Pinkus

目的:探讨免疫组化联合标记区分纤维上皮瘤的组织学类型的意义。方法:对1例纤维上皮瘤、2例基底细胞癌和1例毛发上皮瘤进行免疫组化标记,抗体为AR、CK20、CD34、Bcl-2和Ki-67。结果:纤维上皮瘤AR、CD34、bcl-2和Ki-67的免疫组化结果都与基底细胞癌相似,只有CK20的免疫组化结果与毛发上皮瘤一致。结论:在小样本切除标本中采用联合标记,有助于纤维上皮瘤诊断。

Objective：To study the significance of Coimmunohistochemical stains for fibroepithelioma of Pinkus in differentiating basal cell carcinoma from trichoepithelioma or trichoblastoma. Methods：We studied androgen receptor, cytokeratin 20, CD34, Ki - 67, bcl - 2 immunohistochemical expression in 1 fibroepitheliomas of Pinkus, 2 basal cell carcinomas and 1 trichoepitheliomas. Results：Similar to basal cell carcinomas, fibroepitheliomas of Pinkus expressed androgen receptors, bcl - 2, Ki - 67, potentially supporting classification as a basal cell carcinoma. Conversely, fibroepithelioma of Pinkus demonstrated retention of Merkel cells, a feature of benign follicular tumors. Immunophenotypic evidence for the classification of fibroepithelioma of Pinkus remains inconclusive. Conclusion：In small, partial biopsy specimens, coexpression of androgen receptor, cytokerafin20, cd34, bcl - 2, Ki - 67 may aid the diagnosis of fibroepithelioma of Pinkus.