格林-巴利综合征患者血清及脑脊液中白细胞介素6水平测定

DETECTION OF INTERLEUKIN6 IN SERUM AND CEREBROSPINAL FLUID OF PATIENTS WITH GUILLAINBARRE SYNDROME

应用生物学方法检测了２６例格林－巴利综合征（ＧＢＳ）患者血清及脑脊液中白细胞介素６（ＩＬ－６）含量。结果显示：ＧＢＳ患者血清及脑脊液中ＩＬ－６水平明显高于正常对照组（Ｐ＜０．００１）；血清中ＩＬ－６含量与脑脊液中ＩＬ－６含量无相关性；血清中ＩＬ－６含量与血清免疫球蛋白含量无相关性；但血清免疫球蛋白水平明显高于正常对照组（Ｐ＜０．０１）。

nterleukin6 was measured in cerebrospinal fluid and serum from 26 patients with GuillainBarre syndrome by using bioassay method.The result showed that the levels of interleukin6 in serum and CSF was higher in GBS group than in normal control group (P<0001).There were no correlations between serum IL6 and CSF IL6,and between serum IL6 and serum Ig,but the levels of serum Ig were higher in GBS group than in normal control group (P<0001).The study shows that B cells may be activated in serum of patients with GuillainBarre syndrome.