静脉脂肪乳剂的氧化及其过氧化物分解动力学的实验研究

KINETICS OF OXIDATION AND DECOMPOSITION OF PEROXIDE FOR INTRAVENOUS FAT EMULSION

测定了静脉脂肪乳剂分别在充氮、充氧及空气存在条件下于不同温度下的氧化规律。结果表明，氧的存在是影响脂肪乳剂氧化的最重要因素。同时所测定的脂肪乳剂中过氧化物的分解动力学参数符合一级反应动力学方程，分解活化能Ｅａ为９２．２１ｋＪ·ｍｏｌ－１，２５°Ｃ下的速度常数ｋ为５．５４×１０－４ｈ－１。

The behavior of oxidation for the intravenous fat emulsion was determined under the presence of nitrogen, oxygen or air at different temperature. The results showed that existence of oxygen is the most important factor to affect its oxidation. The decomposition reaction of peroxide in the emulsion conforms to firstorder reaction kinetics. The activation energy Ea is about 92.21 kJ/mol, the reaction velocity constant k is 5.54×10-4 h-1 at 25°C.