预胶化淀粉制备阿昔洛韦胶囊的体外溶出和生物利用度

IN VITRO DISSOLUTION AND BIOAVAILABILITY OF ACYCLOVIR CAPSULES FORMULATED WITH PREGELATINIZED STARCH

以预胶化淀粉为赋型剂，制备阿昔洛韦胶囊，其体外溶出（Ｔ８０＝１０．８８ｍｉｎ）明显快于市售片剂（Ｔ８０＝１５．５２ｍｉｎ）；其人体相对生物利用度的药－时曲线下面积ＡＵＣ＝３．７９７８±０．２６４０μｇ·ｈ／ｍｌ及峰浓度Ｃｍａｘ＝０．５８９±０．０２９μｇ／ｍｌ，显著高于市售片剂，其ＡＵＣ＝１．７７０８±０．１４１９μｇ·ｈ／ｍｌ；Ｃｍａｘ＝０．４８０±０．

The  in vitro release of acyclovir capsules using pregelatinized starch as an excipient was faster than the available tablets. The T80 of capsules was 10.88 min vs. 15.52 min of tablets. The relative bioavailability in human was determined, AUCcap=3.7978±0.2640 μg·h/ml, Cmax=0.589±0.029 μg/ml; and AUCtab=1.7708±0.1419 μg·h/ml, Cmax=0.480±0.023 μg/ml.