溶胶凝胶法合成含锌羟基磷灰石粉体

Sol-Gel Synthesis of Zinc-Substituted Hydroxyapatite

以Ca(NO3)2·4H2O、P2O5和Zn(NO3)2·6H2O的乙醇溶液为原料,用溶胶凝胶法合成含锌羟基磷灰石(Zn-HA)粉体。采用X-射线衍射(XRD)、透射电镜(TEM)、红外光谱(FTIR)、热重差热(TG-DTA)对Zn-HA的晶相、形貌、化学组成和热稳定性进行了分析。结果表明:锌取代部分钙进入HA的晶格中降低了磷灰石的颗粒尺寸;当锌含量低于40χ%时,不会改变HA的晶体结构,但因锌离子半径小于钙离子半径,导致HA的结晶度降低,微晶尺寸减小。TG-DTA分析表明,锌掺入降低HA的热稳定性。

Zinc-substituted hydroxyapatite powders were prepared by sol-gel method using Ca（NO3）2·4H2O, P2O5 and Zn（NOa）2·6H2O as reagents. X-ray diffraction（XRD）, Transmission electron microscopy（TEM）, Fourier transform infrared spectroscopy（FTIR） and thermomechanical analyzer-differential thermechanical analyzer（TG-DTA） were used to characterize the crystalline phase, microstructure, chemical composition and thermal stability of zinc-substituted hydroxyapatite. The results show that the substitution of the zinc ion for calcium ion decrease the particle size of HA; The structure of HA is not changed when the substitution fraction of Zn is below 40x%, however, the ionic radius is smaller in Zn^2＋ （0.074 nm） than in Ca^2＋ （0.099 nm）, which cause a lower crystallinity for HA. Furthermore, the substitutions of the zinc ions restrain the growth of Zn-HA crystal. The amount of zinc incorporated into HA lattice decrease the thermal stability of HA.