水溶性尼泊尔鸢尾异黄酮磺化物的合成及药理活性研究

Studies on synthesis and biological activity of water-soluble irisolidon sulfonate

以尼泊尔鸢尾苷元(5,7-二羟基-4,′6-二甲氧基异黄酮)为原料通过磺化反应合成了水溶性化合物尼泊尔鸢尾异黄酮-3′-磺酸钠(5,7-二羟基-4,′6-二甲氧基异黄酮-3′-磺酸钠),并采用IR,NMR及元素分析法对其结构进行表征。同时进行了抗缺氧活性实验,结果表明尼泊尔鸢尾异黄酮-3′-磺酸钠磺酸钠的水溶性、抗缺氧生理活性优于尼泊尔鸢尾苷元。

Water-soluble irisolidon sulfonate（5,7-hydroxyl-4′,6-dimethoxyl-isoflavone-3′-sulfonate） was synthesized by sulfonation and it was characterized by IR,NMR spectrum and elemental analysis.The biological activities of hypoxia and anoxemia were tested and the results show that the biological activities of resistance to hypoxia and anoxemia of irisolidon sulfonate were better than that of irisolidon.