氯丙嗪、利培酮和奎硫平对精神分裂症患者认知功能的影响

Influence of Quetiapine, Risperidone and Chlorpromazine on cognitive function in schizophrenia

目的：探讨奎硫平、利培酮和氯丙嗪对精神分裂症患者认知功能的影响。方法：90例精神分裂症患者分为奎硫平组（n=30）、利培酮组（n=30）和氯丙嗪组（n=30），在治疗前和治疗后8周进行中国韦氏智力量表（WAIS—RC）中的木块图测验（Block Design），中国韦氏记忆测验（WMS—RG）中的逻辑记忆分测验，威斯康星卡片分类测验（WCST）等神经心理测验。结果：治疗8周后，发现奎硫平组、利堵酮组治疗后两组精神分裂症患者认知功能各项指标均较治疗前有了明显改善，具有统计学差异，氯丙嗪组治疗后认知功能较治疗前无明显改善。结论：奎硫平和利培酮对精神分裂症患者认知功能的改善作用相当，均显著优于氯丙嗪。

Objective：To study the effects of Quetiapine, Risperidone and Chlorpromazine on cognitive function in patients with schizophrenia. Methods ：90 patients with schizophrenia were divided into Quetiapine group （n = 30）, Rispefidone group （n = 30 ） and Chlorpromazine group （ n = 30）. All patients were tested with neuropsychological tests, including Block Design of WAIS - RC, Logical Memory of WMS - RC,Wiconsin Card Sorting test （WCST） before and after 8 weeks treatment. Results： After 8 weeks treatment, all indices of cognitive function improved significantly in patients of Qnetiapine group and Risperidone group, while Chlorpromazine group did not change. Conclusions ： The improvement on cognitive function of Quetiapine is equal to Risperidone, both of them significantly better than chlorpromazine.