利培酮治疗酒中毒所致精神障碍的对照研究

AContrast Study of Risperidone in Treatment of Alcoholism

目的：比较利培酮与奋乃静治疗酒中毒的疗效及安全性。方法：将52例酒中毒患者随机分为两组，分别服用利培酮和奋乃静系统治疗，疗程6周，于治疗前及治疗后第2、4、6周末进行简明精神病量表（BPRS）评定疗效，用不良反应量表（TESS）评定不良反应。结果：利培酮与奋乃静对酒中毒均有显著疗效，两组间差异无显著性，但利培酮的不良反应较奋乃静小。结论：利培酮是一种安全有效的抗精神病药。

Objective：To compare the clinical efficacy and side effects of risperidone and perphenazine in the treatment of Alcoholism. Methods：52 alcoholism patients have been divided into risperidone group and perphenazine group randomly to treat for 6 weeks. BPRS and TESS were used to assess the efficacy and side effect before and 2 weeks ,4weeks and 6weeks after the treatment. Results ： both drugs has marked efficacy in the treatment of alcoholism and there are no significant difference between two groups, risperidone had significantly fever side effects than perphenazine. Conclusions： risperidone is an effective antipsychotic.