艾司西酞普兰与帕罗西汀治疗抑郁症的对照研究

Comparative study between escitalopram and paroxetine in the treatment of depression

目的：观察艾司西酞普兰与帕罗西汀治疗抑郁症的疗效及安全性。方法：将58例抑郁症患者随机分为艾司西酞普兰组和帕罗西汀组，疗程6周。采用汉密尔顿抑郁量表（HAMD），及治疗中出现的症状用量表（TESS）评定疗效和不良反应。结果：艾司西酞普兰组与帕罗西汀组显效率分别为82．7％和75．9％。两组疗效相仿。但治疗1周后，艾司西酞普兰组的有效率高于帕罗西汀组。结论：艾司西酞普兰是一种安全有效的抗抑郁药。

Objective：To observe the clinical efficacy and safety between escitalporam and paroxetine in the treatment of depression. Methods ：58 patients with depression were randomly devided into escitalopram group and paroxetine group for 6 weeks. Hamilton rating scale for depression （HAMD） and treatment emergent symptoms scales（TESS） were used to evaluate the efficacy and adverse effects. Results： The effective rate of escitalopram was 82.7% and paroxetine group was75.9%. Escitalopram group showed a higher response rate compared with paroxetine group after one week treatment. Conclusions： Escitalopram is an effective and safe drug in the treatment of depression.