脑膜瘤的临床、病理学表现与流式细胞术分析的关系

Correlations between the clinical and pathological features of meningioma and flow cytometry analysis

目的：了解脑膜瘤的临床、病理学特征与肿瘤增殖能力的关系。方法：对６８例脑膜瘤标本进行流式细胞术（ＦＣＭ）检测，分析几种临床病理特征与ＦＣＭ的关系。结果：血管型、合体型脑膜瘤超二倍体率、ＤＩ和ＰＩ显著高于纤维型及混合型；重度水肿组ＤＩ、超二倍体率和ＰＩ显著高于中、轻及无水肿组；大肿瘤超二倍体率和ＤＩ均显著高于中、小肿瘤；复发性脑膜瘤的ＤＩ、ＰＩ均显著高于非复发组。结论：通过ＦＣＭ分析可较准确地判定肿瘤的增殖能力。

Objective: To study the relationship between the clinical and pathological features and the proliferative activity of meningioma. Method: The DNA ploidy and the cell kinetics in 68 samples of meningiomas were examined by flow cytometry (FCM), with the relationship between some clinical and pathological features and FCM changes were analysed. Result: The percentage of hyperdiploid cells, DNA Index(DI) and proliferative index(PI) were statistically higher in the vascular and the syncytial subtypes of meningioma than those in the fibrous and mixed subtypes, Also those in the severe edema group were higher than those in the moderate, mild and without peritumoral edema groups. The DNA hyperdiploidy were mostly found in the group of giant size tumor, DI and PI in the recurrent menigioma group were significantly higher than those in the nonrecurrent group. Conclusion: With FCM analysis, the proliferative activity of meningioma could be judged and the clinical measures could be designed.