中枢神经系统肠源性囊肿的形态及免疫组化研究

Morphologic and immunohistochemical study of enterogenous cyst in the central nervous system

目的：观察中枢神经系统肠源性囊肿的组织形态及免疫组织化学特征。方法：使用病理组织学及免疫组织化学方法对３１例中枢神经系统不同部位的肠源性囊肿进行研究。结果：囊肿壁上皮可为单层或复层扁平、立方、柱状上皮；一些病例可见两种以上上皮组织成分，并相互移行；某些病例，在囊肿壁内可含有黑色素、软骨、平滑肌、粘液腺等多种组织成分。免疫组织化学染色ＥＭＡ均呈阳性；ＣＥＡ染色仅一例阴性，而此例ＮＳＥ阳性，故应诊断为神经上皮性囊肿；Ｓ－１００和ＣＫ染色结果不固定；Ｖｉ－ｍｅｎｔｉｎ和ＧＦＡＰ均呈阴性。结论：肠源性囊肿的组织形态和免疫组织化学特点可作为鉴别其他类型囊肿的依据。

Objective: To study the characteristics of histology and immunohistochemistry of enterogenous cyst in the central nervous system. Methods: Histopathological and immunohistochemical examinations were performed in 31 cases. Among these patients, their ages ranged from 15 to 58 years. Results: Enterogenous cyst are most commonly observed in young persons. Histological findings are different from the previous literatures. The cyst walls were lined by a simple or stratified of squamous, cuboidal or columnar epithelium. In some cases, there are two or more epithelium types which transmigrate each other. Visceral muscle, mucous gland and other components within the cyst wall can be found in some cases. All the enterogenous cyst epithelia present EMA immunoreactivity. One of the cases shows CEA negative but NSE positive staining, so it suggested to be a neuroepithelial cyst. S100 and CK immunostaining occurred irregularly in these cases. All the cases did not show Vimentin and GFAP staining. Conclusion: These characteristics of enterogenous cyst are helpful in distinguishing their type from others.