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白介素-2,白介素-13与输卵管粘膜上皮炎的相关性研究 被引量：2

Relationship salpingitis and the expression of interleukine-2,interleukine-13 in mucous epithelium of Fallopian tube.
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摘要 目的探讨血清炎症因子白细胞介素-2(IL-2),白细胞介素-13(IL-13)与输卵管粘膜上皮炎的关系。方法运用免疫组化结合病理图像半定量分析方法,检测30例输卵管粘膜上皮炎壶腹部标本(研究组),30例正常输卵管壶腹部标本(对照组)的表达情况。结果IL-2在研究组输卵管粘膜中阳性表达与对照组比较,有升高趋势,但两组比较无统计学意义(P>0.05);IL-13在研究组输卵管粘膜中阳性表达高于对照组,两组比较有统计学差异(P<0.05);研究组输卵管炎患者粘膜上皮局部IL-2/IL-13显著下降(P<0.05)。结论输卵管慢性炎会引起IL-2,IL-13表达增强,IL-2/IL-13比值下降提示可能出现TH1/TH2细胞的免疫功能失衡。 Obejective： To explore interleukine -2 （IL- 2）, IL- 13 possible mechanisms in mucous epithelium of fallopian tuble. Method： Ampulla of 30 chronic salpingitis （study group）, 30 normal fallopian tube （control group） were selected. Immunohistochemistry and semi -quantity pathologic image software of IL -2, IL - 13 respectively. Results： No significant difference was found for IL - 2 expression between study group and control group （ P 〉 0. 05）, while it was higher in study group than in control group ; The expression of IL - 13 was higher in study group than in control group, and significant difference was found （ P 〈0. 05） ; The ratio of IL -2/IL - 13 was significantly lower than control group in study group （ P 〈0. 05） . Conclusions： The higher expression of IL-2, IL- 13 probably participated in the formation of chronic inflammation of fallopian tube . TH1/TH2may be inbalance in mucous epithelium of fallopian tube pationents.
作者 李莉 黄舒娥 叶明 张秋实
机构地区 广州市妇婴医院
出处 《中国优生与遗传杂志》 2009年第6期45-47,共3页 Chinese Journal of Birth Health & Heredity
关键词 白介素-2 白介素-13 输卵管炎 Interleukine- 2 Interleukine- 13 Mucous epithelium of fallopian tube
分类号 R711.3 [医药卫生—妇产科学]
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参考文献8

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同被引文献14

  • 1任玲龙,郭永建.白细胞介素4与抗病毒感染[J].国际流行病学传染病学杂志,2006,33(3):204-206. 被引量：6
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  • 9Asadullah K, Sterry W, Volk HD. Interleukin - 10 therapy - review of a new approach [J]. Pharmacol Rev, 2003, 55 (2): 241 - 269.
  • 10高新源,许丽绵.许丽绵教授补肾活血法改善子宫内膜容受性经验介绍[J].四川中医,2015,33(6):1-3. 被引量：8

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中国优生与遗传杂志
2009年 第6期

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