摘要
目的探讨血清炎症因子白细胞介素-2(IL-2),白细胞介素-13(IL-13)与输卵管粘膜上皮炎的关系。方法运用免疫组化结合病理图像半定量分析方法,检测30例输卵管粘膜上皮炎壶腹部标本(研究组),30例正常输卵管壶腹部标本(对照组)的表达情况。结果IL-2在研究组输卵管粘膜中阳性表达与对照组比较,有升高趋势,但两组比较无统计学意义(P>0.05);IL-13在研究组输卵管粘膜中阳性表达高于对照组,两组比较有统计学差异(P<0.05);研究组输卵管炎患者粘膜上皮局部IL-2/IL-13显著下降(P<0.05)。结论输卵管慢性炎会引起IL-2,IL-13表达增强,IL-2/IL-13比值下降提示可能出现TH1/TH2细胞的免疫功能失衡。
Obejective: To explore interleukine -2 (IL- 2), IL- 13 possible mechanisms in mucous epithelium of fallopian tuble. Method: Ampulla of 30 chronic salpingitis (study group), 30 normal fallopian tube (control group) were selected. Immunohistochemistry and semi -quantity pathologic image software of IL -2, IL - 13 respectively. Results: No significant difference was found for IL - 2 expression between study group and control group ( P 〉 0. 05), while it was higher in study group than in control group ; The expression of IL - 13 was higher in study group than in control group, and significant difference was found ( P 〈0. 05) ; The ratio of IL -2/IL - 13 was significantly lower than control group in study group ( P 〈0. 05) . Conclusions: The higher expression of IL-2, IL- 13 probably participated in the formation of chronic inflammation of fallopian tube . TH1/TH2may be inbalance in mucous epithelium of fallopian tube pationents.
出处
《中国优生与遗传杂志》
2009年第6期45-47,共3页
Chinese Journal of Birth Health & Heredity
关键词
白介素-2
白介素-13
输卵管炎
Interleukine- 2
Interleukine- 13
Mucous epithelium of fallopian tube