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Toll样受体7及9与系统性红斑狼疮的研究进展 被引量：1

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摘要 系统性红斑狼疮（systemic lupus erythematosus，SLE）是一种病程反复、累及多种器官的自身免疫性疾病，其免疫学特征主要是高滴度的自身抗体和伴随抑制性T淋巴细胞减少的自身反应性B淋巴细胞增多，但机制尚未完全清楚。Toll样受体（toll—like receptors，TLRs）为模式识别受体（pattern recognition receptors，PRRs）中的信号转导受体。
作者 王涛 李志军
机构地区 蚌埠医学院第一附属医院风湿免疫科
出处 《中华微生物学和免疫学杂志》 CAS CSCD 北大核心 2009年第5期478-482,共5页 Chinese Journal of Microbiology and Immunology
关键词 TOLL样受体 系统性红斑狼疮 ERYTHEMATOSUS 自身免疫性疾病 T淋巴细胞减少 淋巴细胞增多 模式识别受体 LUPUS
分类号 R593.241 [医药卫生—内科学]
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参考文献46

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  • 2Medzhitov R, Preston-Hurlburt P, Janeway CA, et al. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature, 1997, 388(6640) : 394-397.
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同被引文献26

  • 1华晶,沈南,陈顺乐,黄新芳,冯学兵,钱捷,张巍.应用荧光定量PCR验证干扰素诱导表达基因在系统性红斑狼疮患者中的表达[J].上海医学,2004,27(8):584-586. 被引量：4
  • 2汤建平,顾越英,沈南,钱捷,陈晓翔,黄新芳,黄向阳,梁栋,郭强,杨程德,鲍春德,陈顺乐.系统性红斑狼疮患者外周血干扰素基因的定量表达[J].中华内科杂志,2005,44(2):106-110. 被引量：8
  • 3Bennett L,Palucka AK,Arce E,et al.Interferon and granulopoiesis signatures in systemic lupus erythematosus blood[J].J Exp Med,2003,197(6):711-723.
  • 4Kirou KA,Lee C,George S,et al.Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus[J].Arthritis Rheum,2004,50(12):3958-3967.
  • 5Yang YG,Lindahl T,Barnes DE.Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease[J].Cell,2007,131(5):873-886.
  • 6Crow YJ,Hayward BE,Parmar R,et al.Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus[J].Nat Genet,2006,38(8):917-920.
  • 7Lee-Kirsch MA,Gong M,Chowdhury D,et al.Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus[J].Nat Genet,2007,39(9):1065-1067.
  • 8de Silva U,Choudhury S,Bailey SL,et al.The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering[J].J Biol Chem,2007,282(14):10537-10543.
  • 9Hoss M,Robins P,Naven TJ,et al.A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein[J].EMBO J,1999,18(13):3868-3875.
  • 10Mazur DJ,Perrino FW.Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'→5' exonucleases[J].J Biol Chem,1999,274(28):19655-19660.

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中华微生物学和免疫学杂志
2009年 第5期

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