冠心病患者纤溶指标及血栓弹力图变化意义的研究

Significance of the changes of fibrinolysis and thrombus elasticity graph (TEG)in patients with coronary heart disease

目的：探讨纤溶指标及血栓弹力图改变对各类型冠心病的意义。方法：测定冠心病患者组织型纤溶酶原激活物（ｔ－ＰＡ），纤溶酶原激活物抑制物（ＰＡＩ），Ｄ－二聚体（Ｄ－ｄｍ）及血栓弹力图（ＴＥＧ）的变化。结果：纤溶改变在冠心病组与对照组有非常显著性差异（Ｐ＜０．０１），急性心肌梗塞（ＡＭＩ）、不稳定心绞痛组（ＵＡ）及隐匿型冠心病组（ＬＣＨ）组间有显著性差异（Ｐ＜０．０５）；而ＴＥＧ改变在对照组与各类型冠心病组间有显著性差异（Ｐ＜０．０１），各类型冠心病组间无显著性差异（Ｐ＞０．０５）。结论：ｔ－ＰＡ、ＰＡＩ活性、Ｄ－ｄｍ含量测定及ＴＥＧ的高凝图像改变可作为冠心病诊断及病程发展的指标。

\ Objective :To explore the signifincance of the change of fibrinolytic indices and thrombus elastictiy graph(TEG)in the patients with coronary heart diseaseMethods:To assay the change of the tissue plasminogen activator(t-PA),plasminogen activator inhibitor(PAI),D-dimer (D-dm)and thrombus elasticity graph (TEG)in the patients with coronary heart diseaseResults:In the fibrinolytic change,there were much more significant differences between the CHD group and the control group (P<001),and there were also significant differences among the acute myocardial infarction(AMI) groups,the unstable angina pectoris(UA)and the latent coronary heart disease (LCH)(P<005)In the change of TEG,there were significant differences betwecn the control group and all sorts of coronary heart disease (P<001),and there were not significant differences among all sorts of CHDConclusion:The results showed that the change of t-PA、PAI and D-dimer level and hypercoagulable state of TEG could be the index of the diagnosis and clinical development of CHD \ \