摘要
应用抗人胃癌单克隆抗体MG系列建立了免疫放射分析法(IRMA),用以测定胃癌血清中MG系列的相关抗原(MG-AgS)。64名健康献血员血清中MG-AgS的平均含量为7.1±4.4U/ml,以20U/ml为正常值上限,健康献血员无一例超过此标准;慢性胃炎38例阳性率为10.5％(4/38),胃癌63例阳性率高达63.8％(43/63)。提示本法灵敏度高、结果可靠。有助于胃癌的常规诊断,并可用作胃癌普查的初筛手段之一。
An immunoradiometric assay has been established by means of a panel of monoclonal antibodies against gastric cancer to quantitate tumor associated antigens(MG-AgS) in sera of patients with gastric cancer.The mean concentration of MG-AgS in sera of 64 healthy blood donors was 7.1±4.4U/ml.If the upper limit of normal range was set at 20U/ml of serum,none of healthy donors was positive,and only 10.5%(4/38) of sera of patients with chronic gastritis were positive,whereas 68.3%(43/63) of sera of gastric cancer patients were positive.The results suggest that this assay might be useful in serological diagnosis and mass screening survey of gastric cancer.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
1990年第1期1-3,共3页
Medical Journal of Chinese People's Liberation Army
关键词
胃肿瘤
单克隆抗体
抗原
诊断
Stomach neoplasm Monoclonal antibody Tumor associated antigen Serological diagnosis
